Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential

YL Xiao, Y Gong, YJ Qi, ZM Shao… - Signal Transduction and …, 2024 - nature.com
Diet, serving as a vital source of nutrients, exerts a profound influence on human health and
disease progression. Recently, dietary interventions have emerged as promising adjunctive …

Major roles of kupffer cells and macrophages in NAFLD development

SJ Park, J Garcia Diaz, E Um, YS Hahn - Frontiers in Endocrinology, 2023 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is an important public health problem with growing
numbers of NAFLD patients worldwide. Pathological conditions are different in each stage of …

[HTML][HTML] HIGD1A links SIRT1 activity to adipose browning by inhibiting the ROS/DNA damage pathway

BY Li, WQ Peng, Y Liu, L Guo, QQ Tang - Cell reports, 2023 - cell.com
Energy-dissipating adipocytes have the potential to improve metabolic health. Here, we
identify hypoxia-induced gene domain protein-1a (HIGD1A), a mitochondrial inner …

Functional role of skeletal muscle-derived interleukin-6 and its effects on lipid metabolism

W Lin, H Song, J Shen, J Wang, Y Yang… - Frontiers in …, 2023 - frontiersin.org
The detrimental impact of obesity on human health is increasingly evident with the rise in
obesity-related diseases. Skeletal muscle, the crucial organ responsible for energy balance …

Short-term strength exercise reduces the macrophage M1/M2 ratio in white adipose tissue of obese animals

CJ da Costa Fernandes, KC da Cruz Rodrigues… - Life sciences, 2023 - Elsevier
Obesity can exacerbate the systemic inflammatory process, leading to increased infiltration
of monocytes in white adipose tissue (WAT) and polarization of these cells into pro …

Epidermal growth factor receptor activation is essential for kidney fibrosis development

S Cao, Y Pan, AS Terker, JP Arroyo Ornelas… - Nature …, 2023 - nature.com
Fibrosis is the progressive accumulation of excess extracellular matrix and can cause organ
failure. Fibrosis can affect nearly every organ including kidney and there is no specific …

Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity‐related diseases

L Li, P Wang, X Jiao, S Qin, Z Liu, Y Ye… - Obesity …, 2024 - Wiley Online Library
Obesity, a burgeoning worldwide health system challenge, is associated with multiple
chronic diseases, including diabetes and chronic inflammation. Fatty acid esters of hydroxy …

Large yellow tea polysaccharides ameliorate obesity-associated metabolic syndrome by promoting M2 polarization of adipose tissue macrophages

H Wang, L Wang, H Cheng, H Ge, Z Xie, D Li - Food & Function, 2023 - pubs.rsc.org
Obesity-induced metabolic syndrome is strongly associated with infiltrated adipose tissue
macrophages (ATMs). Large yellow tea, a traditional functional beverage in China, has been …

Mechanisms of abnormal lipid metabolism in the pathogenesis of disease

L Xu, Q Yang, J Zhou - International Journal of Molecular …, 2024 - pmc.ncbi.nlm.nih.gov
Lipid metabolism is a critical component in preserving homeostasis and health, and lipids
are significant chemicals involved in energy metabolism in living things. With the growing …

Genome‐wide DNA methylation analysis of body composition in Chinese monozygotic twins

H Tian, H Qiao, F Han, X Kong, S Zhu… - European Journal of …, 2023 - Wiley Online Library
Background Little is currently known about epigenetic alterations associated with body
composition in obesity. Thus, we aimed to explore epigenetic relationships between …