Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

Abnormalities of diastolic function are common to virtually all forms of cardiac failure.
However, their underlying mechanisms, precise role in the generation and phenotypic …

Overload of neonatal and adult cardiomyocytes and mul-ticellular myocardial preparations,
which include whole hearts, are accompanied by an enhanced activity of the Na+/H+ …

The animal models of myocardial injury induced by systemic β-adrenergic receptor agonist
administration represent an experimental approach of persisting interest. These models …

Bicarbonate is a simple single carbon molecule that plays surprisingly important roles in
diverse biological processes. Among these are photosynthesis, the Krebs cycle, whole-body …

The Na+/H+ exchanger (NHE) is a ubiquitous protein present in mammalian cells. In higher
eukaryotes this integral membrane protein removes one intracellular H+ for one extracellular …

We determined the effect of 24-hour aldosterone (100 nmol/L) treatment on hypertrophic
responses in rat neonatal ventricular myocytes and the possible role of Na+-H+ exchange …

Sodium/hydrogen exchange (NHE) inhibitors show promise as potential therapeutic agents
for the treatment of heart failure, but it is not known whether they can reverse the …

Extensive pre-clinical work indicates that inhibition of the Na+/H+ exchanger (NHE) affords
significant protection to myocardium subjected to ischaemia and reperfusion. By contrast …

The adaptive changes that develop in the pressure-overloaded left ventricular (LV)
myocardium include cardiomyocyte hypertrophy and interstitial fibrosis. Although the former …