Higher-order transient membrane protein structures
This study shows that five membrane proteins—three GPCRs, an ion channel, and an
enzyme—form self-clusters under natural expression levels in a cardiac-derived cell line …
enzyme—form self-clusters under natural expression levels in a cardiac-derived cell line …
The role of G Protein-Coupled Estrogen Receptor (GPER) in vascular pathology and physiology
F Xu, J Ma, X Wang, X Wang, W Fang, J Sun, Z Li, J Liu - Biomolecules, 2023 - mdpi.com
Objective: Estrogen is indispensable in health and disease and mainly functions through its
receptors. The protection of the cardiovascular system by estrogen and its receptors has …
receptors. The protection of the cardiovascular system by estrogen and its receptors has …
Emerging modes of regulation of neuromodulatory G protein-coupled receptors
In the nervous system, G protein-coupled receptors (GPCRs) control neuronal excitability,
synaptic transmission, synaptic plasticity, and, ultimately, behavior through spatiotemporally …
synaptic transmission, synaptic plasticity, and, ultimately, behavior through spatiotemporally …
Correlative single-molecule and structured illumination microscopy of fast dynamics at the plasma membrane
Total internal reflection fluorescence (TIRF) microscopy offers powerful means to uncover
the functional organization of proteins in the plasma membrane with very high spatial and …
the functional organization of proteins in the plasma membrane with very high spatial and …
Membrane topography and the overestimation of protein clustering in single molecule localisation microscopy–identification and correction
According to single-molecule localisation microscopy almost all plasma membrane proteins
are clustered. We demonstrate that clusters can arise from variations in membrane …
are clustered. We demonstrate that clusters can arise from variations in membrane …
Cell swelling enhances ligand-driven β-adrenergic signaling
A Sirbu, M Bathe-Peters, JLM Kumar, A Inoue… - Nature …, 2024 - nature.com
G protein-coupled receptors' conformational landscape can be affected by their local,
microscopic interactions within the cell plasma membrane. We employ here a pleiotropic …
microscopic interactions within the cell plasma membrane. We employ here a pleiotropic …
Structural Rearrangement of the AT1 Receptor Modulated by Membrane Thickness and Tension
B Poudel, JM Vanegas - The Journal of Physical Chemistry B, 2024 - ACS Publications
Membrane-embedded mechanosensitive (MS) proteins, including ion channels and G-
protein coupled receptors (GPCRs), are essential for the transduction of external mechanical …
protein coupled receptors (GPCRs), are essential for the transduction of external mechanical …
[HTML][HTML] GPCRs in the round: SMA-like copolymers and SMALPs as a platform for investigating GPCRs
H Ayub, RJ Murray, GC Kuyler, F Napier-Khwaja… - Archives of Biochemistry …, 2024 - Elsevier
G-protein-coupled receptors (GPCRs) are the largest family of membrane proteins, regulate
a plethora of physiological responses and are the therapeutic target for 30–40% of clinically …
a plethora of physiological responses and are the therapeutic target for 30–40% of clinically …
Approximating particle-based clustering dynamics by stochastic PDEs
This work proposes stochastic partial differential equations (SPDEs) as a practical tool to
replicate clustering effects of more detailed particle-based dynamics. Inspired by membrane …
replicate clustering effects of more detailed particle-based dynamics. Inspired by membrane …
Investigations of membrane protein interactions in cells using fluorescence microscopy
The interactions between proteins in membranes govern many cellular functions. Our ability
to probe for such interactions has greatly evolved in recent years due to the introduction of …
to probe for such interactions has greatly evolved in recent years due to the introduction of …