Integrins, and integrin-mediated adhesions, have long been recognized to provide the main
molecular link attaching cells to the extracellular matrix (ECM) and to serve as bidirectional …

Neuroblastoma is a leading cause of cancer-related death in children. Accumulated data
suggest that differentiation arrest of the neural-crest-derived sympathoadrenal lineage …

Collective cell migration is essential for morphogenesis, tissue remodelling and cancer
invasion,. In vivo, groups of cells move in an orchestrated way through tissues. This …

Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Embryonic development is characterized by rapidly dividing cells, cellular plasticity and a
highly vascular microenvironment. These features are similar to those of tumour tissue, in …

The neural crest (NC) is a highly migratory multipotent cell population that forms at the
interface between the neuroepithelium and the prospective epidermis of a developing …

Ribosome biogenesis is a canonical hallmark of cell growth and proliferation. Here we show
that execution of Epithelial-to-Mesenchymal Transition (EMT), a migratory cellular program …

Collective cell chemotaxis, the directed migration of cell groups along gradients of soluble
chemical cues, underlies various developmental and pathological processes. We use neural …

Cell movements are essential for animal development and homeostasis but also contribute
to disease. Moving cells typically extend protrusions towards a chemoattractant, adhere to …

Abstract BACKGROUND Endometriosis affects 6–10% of women of reproductive age and is
associated with chronic pelvic pain, dysmenorrhoea, dyspareunia and infertility …