A key element of the European Union's Human Brain Project (HBP) and other large-scale
brain research projects is the simulation of large-scale model networks of neurons. Here, we …

The most recent genome-wide association studies (GWAS) of schizophrenia (SCZ) identified
hundreds of risk variants potentially implicated in the disease. Further, novel statistical …

Although sentences unfold sequentially, one word at a time, most linguistic theories propose
that their underlying syntactic structure involves a tree of nested phrases rather than a linear …

The human brain displays a rich repertoire of states that emerge from the microscopic
interactions of cortical and subcortical neurons. Difficulties inherent within large-scale …

The digital neuromorphic hardware SpiNNaker has been developed with the aim of
enabling large-scale neural network simulations in real time and with low power …

Recordings of extracellular electrical, and later also magnetic, brain signals have been the
dominant technique for measuring brain activity for decades. The interpretation of such …

Electroencephalograms (EEGs) display a mixture of rhythmic and broadband fluctuations,
the latter manifesting as an apparent 1/f spectral trend. While network oscillations are known …

The local field potential (LFP) is generated by large populations of neurons, but unitary
contribution of spiking neurons to LFP is not well characterised. We investigated this …

The NEURON simulator has been developed over the past three decades and is widely
used by neuroscientists to model the electrical activity of neuronal networks. Large network …

Highlights•Generalized integrate-and-fire (GIF) models permit efficient extraction of point
neuron parameters, which reproduce the spiking behavior of multiple cell types and are …