The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

The members of the transforming growth factor β (TGF-β) superfamily are essential
regulators of cell differentiation, phenotype and function, and have been implicated in the …

The heart is the central organ of the circulatory system, and its proper development is vital
for maintaining human life. Here, we used single-cell RNA sequencing to profile the gene …

Abstract Bone Morphogenetic Proteins (BMPs) are a group of signaling molecules that
belongs to the Transforming Growth Factor-β (TGF-β) superfamily of proteins. Initially …

Left ventricular non-compaction, the most recently classified form of cardiomyopathy, is
characterised by abnormal trabeculations in the left ventricle, most frequently at the apex. It …

The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

Cardiogenesis is a complex developmental process involving multiple overlapping stages of
cell fate specification, proliferation, differentiation, and morphogenesis. Precise …

The mammalian proprotein convertases constitute a family of nine secretory serine
proteases that are related to bacterial subtilisin and yeast kexin. Seven of these (proprotein …

Congenital heart disease (CHD) is one of the most common birth defects. Studies in animal
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …

Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the
Transforming Growth Factor Beta superfamily. To date over 20 members have been …