Classification of esophageal motor findings in gastro‐esophageal reflux disease: conclusions from an international consensus group
CP Gyawali, S Roman, AJ Bredenoord… - …, 2017 - Wiley Online Library
Background High‐resolution manometry (HRM) has resulted in new revelations regarding
the pathophysiology of gastro‐esophageal reflux disease (GERD). The impact of new HRM …
the pathophysiology of gastro‐esophageal reflux disease (GERD). The impact of new HRM …
NERD: an umbrella term including heterogeneous subpopulations
Nonerosive reflux disease (NERD) represents the more common phenotypic presentation of
GERD and comprises patients who have typical symptoms without any mucosal breaks at …
GERD and comprises patients who have typical symptoms without any mucosal breaks at …
Type 2 inflammation in eosinophilic esophagitis: from pathophysiology to therapeutic targets
F Racca, G Pellegatta, G Cataldo, E Vespa… - Frontiers in …, 2022 - frontiersin.org
Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus
characterized clinically by symptoms related to esophageal dysfunction and histologically by …
characterized clinically by symptoms related to esophageal dysfunction and histologically by …
Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis
Recent data suggest that the interaction between gastroesophageal reflux disease (GERD)
and eosinophilic esophagitis can be complex, and that the notion of establishing a clear …
and eosinophilic esophagitis can be complex, and that the notion of establishing a clear …
Epithelial-intrinsic defects in TGFβR signaling drive local allergic inflammation manifesting as eosinophilic esophagitis
K Laky, JL Kinard, JM Li, IN Moore, J Lack… - Science …, 2023 - science.org
Allergic diseases are a global health challenge. Individuals harboring loss-of-function
variants in transforming growth factor–β receptor (TGFβR) genes have an increased …
variants in transforming growth factor–β receptor (TGFβR) genes have an increased …
Long-term maintenance effect of radiofrequency energy delivery for refractory GERD: a decade later
M Noar, P Squires, E Noar, M Lee - Surgical endoscopy, 2014 - Springer
Background Patients with gastroesophageal reflux disease (GERD) often seek alternative
therapy for inadequate symptom control, with over 40% not responding to medical treatment …
therapy for inadequate symptom control, with over 40% not responding to medical treatment …
The integrity of the esophageal mucosa. Balance between offensive and defensive mechanisms
RC Orlando - Best practice & research Clinical gastroenterology, 2010 - Elsevier
Heartburn is the most common and characteristic symptom of gastroesophageal reflux
disease. It ultimately results from contact of refluxed gastric acid with nociceptors within the …
disease. It ultimately results from contact of refluxed gastric acid with nociceptors within the …
Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis
F Rieder, P Biancani, K Harnett… - American Journal of …, 2010 - journals.physiology.org
Gastroesophageal reflux disease (GERD) is one of the most common problems in clinical
practice today. It is widely believed that functional and structural abnormalities of the …
practice today. It is widely believed that functional and structural abnormalities of the …
T-helper 2 cytokines, transforming growth factor β1, and eosinophil products induce fibrogenesis and alter muscle motility in patients with eosinophilic esophagitis
F Rieder, I Nonevski, J Ma, Z Ouyang, G West… - Gastroenterology, 2014 - Elsevier
Background & Aims Patients with eosinophilic esophagitis (EoE) often become dysphagic
from the combination of organ fibrosis and motor abnormalities. We investigated …
from the combination of organ fibrosis and motor abnormalities. We investigated …
Gastroesophageal reflux disease–associated esophagitis induces endogenous cytokine production leading to motor abnormalities
F Rieder, L Cheng, KM Harnett, A Chak, GS Cooper… - Gastroenterology, 2007 - Elsevier
Background & Aims: Gastroesophageal reflux disease is a condition frequently associated
with esophagitis and motor abnormalities. Recent evidence suggests that proinflammatory …
with esophagitis and motor abnormalities. Recent evidence suggests that proinflammatory …