Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

Background Delirium is defined as a disturbance in attention, awareness and cognition with
reduced ability to direct, focus, sustain and shift attention, and reduced orientation to the …

Sleep is controlled by two major regulatory systems: a circadian system that drives 24-h
periodicity (Process C), and a homeostatic system (Process S) that ensures adequate …

Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO),
and despite decades of research, novel initiatives are drastically needed. According to the …

Background: Sleep and circadian disruption (SCD) is common and severe in the ICU. On the
basis of rigorous evidence in non-ICU populations and emerging evidence in ICU …

Delirium is a syndrome characterized by acute brain failure resulting in neurocognitive
disturbances affecting attention, awareness, and cognition. It is highly prevalent among …

Circadian rhythms are deeply rooted in the biology of virtually all organisms. The pervasive
use of artificial lighting in modern society disrupts circadian rhythms and can be detrimental …

Patients in an intensive care unit (ICU) may risk disruption of their circadian rhythm. In an
intervention research project a cycled lighting system was set up in an ICU room to support …

Objectives: Circadian rhythms are severely disrupted among the critically ill. These circadian
arrhythmias impair mentation, immunity, autonomic function, endocrine activity, hormonal …

Background Disturbed circadian rhythm is a potentially modifiable cause of delirium among
patients in intensive-care units (ICUs). Bright-light therapy in the daytime can realign …