The SAMP-/RAMP-hydrazone methodology in asymmetric synthesis

A Job, CF Janeck, W Bettray, R Peters, D Enders - Tetrahedron, 2002 - Elsevier
The formation of carbon±carbon or carbon±heteroatom bonds adjacent to a carbonyl group
in a regio-, diastereoand enantioselective manner is one of the most important procedures in …

Synthetic approaches to the neuraminidase inhibitors zanamivir (Relenza) and oseltamivir phosphate (Tamiflu) for the treatment of influenza

J Magano - Chemical reviews, 2009 - ACS Publications
Influenza, a severe viral infection of the respiratory system, is responsible for a significant
morbidity and mortality due to both annual epidemics and unpredictable pandemics. In the …

[PDF][PDF] A practical synthesis of (-)-oseltamivir

N Satoh, T Akiba, S Yokoshima… - … EDITION IN ENGLISH-, 2007 - ccc.chem.pitt.edu
• The avian H5N1 influenza shows a lethality rate of over 50%• Three types of influenza
viruses (A, B and C) have different proteins• Inhibitors of the M2 protein (amantadine and …

Convergent Synthesis of Diverse Tetrahydropyridines via Rh (I)-Catalyzed C–H Functionalization Sequences

T Mesganaw, JA Ellman - Organic Process Research & …, 2014 - ACS Publications
A Rh-catalyzed C–H bond activation/alkenylation/electrocyclization cascade reaction
provides diverse 1, 2-dihydropyridines from simple and readily available precursors. The …

A practical synthesis of (−)-oseltamivir

N Satoh, T Akiba, S Yokoshima, T Fukuyama - Tetrahedron, 2009 - Elsevier
Oseltamivir phosphate (Tamiflu®) is a potent inhibitor of neuraminidase, and is used
worldwide as a drug for type A or B influenza. The industrial synthesis of oseltamivir uses …

Synthesis of Isoquinuclidines from Highly Substituted Dihydropyridines via the Diels–Alder Reaction

RM Martin, RG Bergman, JA Ellman - Organic letters, 2013 - ACS Publications
A stereo-and regioselective Diels–Alder reaction for the synthesis of highly substituted
isoquinuclidines from dihydropyridines and electron-deficient alkenes has been developed …

The first catalytic enantioselective Diels–Alder reactions of 1, 2-dihydropyridine: efficient syntheses of optically active 2-azabicyclo [2.2. 2] octanes with chiral BINAM …

N Takenaka, Y Huang, VH Rawal - Tetrahedron, 2002 - Elsevier
We have synthesized a new family of enantiomerically enriched BINAM-derived Schiff base
Cr (III) complexes and evaluated them as catalysts for Diels–Alder reactions. These …

Bicyclic β-amino acids

OO Grygorenko - Tetrahedron, 2015 - Elsevier
The field of β-amino acids and β-peptides has given rise to considerable interest in recent
decades. 1, 1 (a), 1 (b), 1 (c), 1 (d), 1 (e), 1 (f) β-Amino acids are widespread in the nature as …

Discovery and activity of (1R, 4S, 6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1, 1-dimethylethyl) amino] carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl) methyl]-2-oxoethyl]-2-methyl-2 …

Z Ye, L Guo, KJ Barakat, PG Pollard, BL Palucki… - Bioorganic & medicinal …, 2005 - Elsevier
Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide
(3, RY764), a potent and selective melanocortin subtype-4 receptor agonist - ScienceDirect …

Regioselectivity of the reactions of pyridinium and quinolinium salts with various nucleophiles

IS Poddubnyi - Chemistry of Heterocyclic Compounds, 1995 - Springer
Regioselectivity of the reactions of pyridinium and quinolinium salts with various nucleophiles
(Review) Page 1 Chemist~ of Heteroo, clic Compounds, Vol. 31, No. 6, 1995 …