The mammalian visual system encodes information over a remarkable breadth of
spatiotemporal scales and light intensities. This performance originates with its complement …

Rhodopsins are photoreceptive membrane proteins consisting of a common heptahelical
transmembrane architecture that contains a retinal chromophore. Rhodopsin was first …

The opsin family of G-protein-coupled receptors are used as light detectors in animals.
Opsin 5 (also known as neuropsin or OPN5) is a highly conserved opsin that is sensitive to …

The increasing global prevalence of myopia calls for elaboration of the pathogenesis of this
disease. Here, we show that selective ablation and activation of intrinsically photosensitive …

Resveratrol modulates the transcription factor NF-κB, cytochrome P450 isoenzyme CYP1A1,
expression and activity of cyclooxygenase (COX) enzymes, Fas/Fas ligand mediated …

Nearly all mammalian tissues have functional, autonomous circadian clocks, which free-run
with non-24 h periods and must be synchronized (entrained) to the 24 h day. This …

We live on a planet that is bathed in daily and seasonal sunlight cycles. In this context,
terrestrial life forms have evolved mechanisms that directly harness light energy (plants) or …

The fundamental pathophysiologic response for the survival of all organisms is the process
of wound healing. Inadequate or lack of healing constitutes the etiopathologic basis of many …

The consensus on the effects of excessive sun exposure on human health has long
emphasized the negative effects of solar UV radiation. Nevertheless, although UV radiation …

Sensory receptors that detect and respond to light, taste, and smell primarily belong to the G-
protein-coupled receptor (GPCR) superfamily. In addition to their established roles in the …