MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical
cellular processes, a number of which are involved in host defense mechanisms. In …

RSV is a leading cause of respiratory tract disease in infants and the elderly. RSV has
limited therapeutic interventions and no FDA-approved vaccine. Gaps in our understanding …

MicroRNAs (miRs) are single-stranded RNAs of 18-25 nucleotides. These molecules
regulate gene expression at the post-transcriptional level; several of these are differentially …

Respiratory syncytial virus (RSV) is a major cause of serious lower respiratory tract
infections in children< 5 years of age worldwide and repeated infections throughout life …

Over time, more and more is becoming known about micro-players of great significance.
This is particularly the case for microRNAs (miRNAs; miR), which have been found to …

Introduction Respiratory syncytial virus (RSV) is a leading cause of serious lower respiratory
tract infection (LRTI) in infants and young children. Palivizumab is an RSV-specific …

Recent high-throughput sequencing revealed that only 2% of the transcribed human
genome codes for proteins, while the majority of transcriptional products are non-coding …

Prostaglandin D2 (PGD2) signals through PGD2 receptor 2 (DP2, also known as CRTH2) on
type 2 effector cells to promote asthma pathogenesis; however, little is known about its role …

Highlights•Immunological goals for vaccination depend on whether it is for primary induction
or boosting of pre-existing immunity.•Boosting neutralizing activity is the major goal for …

Background: Respiratory syncytial virus (RSV) is a poor inducer of antiviral interferon (IFN)
responses which result in incomplete immunity and RSV disease. Several RSV proteins …