HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

GPCRs (G-protein [guanine nucleotide-binding protein]–coupled receptors) play a central
physiological role in the regulation of cardiac function in both health and disease and thus …

Heterotrimeric G proteins are key players in transmembrane signaling by coupling a huge
variety of receptors to channel proteins, enzymes, and other effector molecules. Multiple …

Serotonin (5-hydroxytryptamine; 5-HT) is a monoamine neurotransmitter whose effects are
mediated by at least 13 distinct G protein-coupled receptors (GPCRs) of the type A family …

Hydroxytryptamine (5-HT; serotonin) was discovered more than 60 years ago as a
substance isolated from blood. The neural effects of 5-HT have been well investigated and …

Oxidative stress can be generated at several sites within the mitochondria. Among these,
monoamine oxidase (MAO) has been described as a prominent source. MAOs are …

The gastrointestinal tract serves the physiological function of digesting and absorbing
nutrients from food and physically mixing and propelling these contents in an oral to anal …

Carcinoid heart disease was one of the first valvular pathologies studied in molecular detail,
and early research identified serotonin produced by oncogenic enterochromaffin cells as the …

Carcinoid heart disease (CHD) is a rare cardiac manifestation occurring in patients with
advanced neuroendocrine tumours and the carcinoid syndrome, usually involving the right …

Hypertension affects an estimated 103 million Americans, yet gaps in knowledge continue to
limit its successful management. Rapidly emerging evidence is linking gut dysbiosis to many …