Ovarian damage from chemotherapy and current approaches to its protection

N Spears, F Lopes, A Stefansdottir… - Human reproduction …, 2019 - academic.oup.com
Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

Revisiting the therapeutic potential of tocotrienol

R Ranasinghe, M Mathai, A Zulli - Biofactors, 2022 - Wiley Online Library
The therapeutic potential of the tocotrienol group stems from its nutraceutical properties as a
dietary supplement. It is largely considered to be safe when consumed at low doses for …

Ameliorating effects of natural antioxidant compounds on female infertility: a review

JK Bhardwaj, H Panchal, P Saraf - Reproductive sciences, 2021 - Springer
The prevalence of female infertility cases has been increasing at a frightening rate, affecting
approximately 48 million women across the world. However, oxidative stress has been …

The impact of chemotherapy on the ovaries: molecular aspects and the prevention of ovarian damage

C Sonigo, I Beau, N Binart, M Grynberg - International journal of …, 2019 - mdpi.com
Cancer treatment, such as chemotherapy, induces early ovarian follicular depletion and
subsequent infertility. In order to protect gametes from the gonadotoxic effects of …

Are vitamin e supplementation beneficial for female gynaecology health and diseases?

NA Md Amin, SH Sheikh Abdul Kadir, AH Arshad… - Molecules, 2022 - mdpi.com
Vitamin E is known as an essential vitamin, and many studies had demonstrated the
importance of vitamin E throughout the reproductive process, such as miscarriage …

Protective effects of antioxidants on cyclophosphamide-induced ovarian toxicity

RS Barberino, RLS Silva… - Biopreservation and …, 2023 - liebertpub.com
The most common limitation of anticancer chemotherapy is the injury to normal cells.
Cyclophosphamide, which is one of the most widely used alkylating agents, can cause …

Randomized controlled open‐label study of the effect of vitamin E supplementation on fertility in clomiphene citrate‐resistant polycystic ovary syndrome

AA Morsy, NA Sabri, AM Mourad… - Journal of Obstetrics …, 2020 - Wiley Online Library
Aim To evaluate the effect of vitamin E on ovulation and pregnancy in women with
clomiphene citrate (CC)‐resistant polycystic ovary syndrome (PCOS). Methods A …

Do quercetin and vitamin E properties preclude doxorubicin-induced stress and inflammation in reproductive tissues?

M Samare-Najaf, F Zal, N Jamali… - Current Cancer …, 2022 - ingentaconnect.com
Background: In recent decades, the exposure to doxorubicin (DOX) has elevated due to the
increment in the incidence of cancer, especially among the young population, which, despite …

Chemotherapy induced oxidative stress in the ovary: drug-dependent mechanisms and potential interventions

M Trujillo, AK Odle, N Aykin-Burns… - Biology of …, 2023 - academic.oup.com
Cancer incidence and relative survival are expected to increase over the next few decades.
With the majority of patients receiving combinatorial chemotherapy, an increasing proportion …

The future of fertility preservation for women treated with chemotherapy

LR Alesi, QN Nguyen, JM Stringer… - Reproduction and …, 2023 - raf.bioscientifica.com
Cytotoxic chemotherapies have been a mainstay of cancer treatment but are associated with
numerous systemic adverse effects, including impacts on fertility and endocrine health …