Legionella pneumophila and Coxiella burnetii are two evolutionarily related intracellular
pathogens that use the Dot/Icm type IV secretion system to translocate effectors into host …

Abstract The phosphatidylinositol 4-kinases (PI4Ks) synthesize phosphatidylinositol 4-
phosphate (PI4P), a key member of the phosphoinositide family. PI4P defines the …

Intracellular pathogens manipulate host organelles to support replication within cells. For
Legionella pneumophila, the bacterium translocates proteins that establish an endoplasmic …

L egionella species are ubiquitous, waterborne bacteria that thrive in numerous ecological
niches. Yet, in contrast to many other environmental bacteria, L egionella spp. are also able …

Many bacterial pathogens have evolved the ability to subvert and exploit host functions in
order to enter and replicate in eukaryotic cells. For example, bacteria have developed …

During infection, Legionella pneumophila translocates over 300 effector proteins into the
host cytosol, allowing the pathogen to establish an endoplasmic reticulum (ER)-like …

Regulation through post‐translational ubiquitin signaling underlies a large portion of
eukaryotic biology. This has not gone unnoticed by invading pathogens, many of which have …

The activity of proteins delivered into host cells by the Dot/Icm injection apparatus allows
Legionella pneumophila to establish a niche called the Legionella-containing vacuole …

To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …

Abstract The Legionella pneumophila Sde family of translocated proteins promotes host
tubular endoplasmic reticulum (ER) rearrangements that are tightly linked to phosphoribosyl …