Inter-tissue communication in cancer cachexia

JM Argilés, B Stemmler, FJ López-Soriano… - Nature Reviews …, 2019 - nature.com
Cachexia is a systemic condition that occurs during many neoplastic diseases, such as
cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by …

Regression of cardiac hypertrophy in health and disease: mechanisms and therapeutic potential

TG Martin, MA Juarros, LA Leinwand - Nature Reviews Cardiology, 2023 - nature.com
Left ventricular hypertrophy is a leading risk factor for cardiovascular morbidity and mortality.
Although reverse ventricular remodelling was long thought to be irreversible, evidence from …

Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia

V Rausch, V Sala, F Penna, PE Porporato, A Ghigo - Oncogenesis, 2021 - nature.com
Cachexia is a severe complication of cancer that adversely affects the course of the disease,
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …

Cancer cachexia: more than skeletal muscle wasting

SF Schmidt, M Rohm, S Herzig, MB Diaz - Trends in cancer, 2018 - cell.com
Cancer cachexia is a multifactorial condition characterized by body weight loss that
negatively affects quality of life and survival of patients with cancer. Despite the clinical …

Subcutaneous Ehrlich Ascites Carcinoma mice model for studying cancer-induced cardiomyopathy

S Mishra, AK Tamta, M Sarikhani, PA Desingu… - Scientific reports, 2018 - nature.com
Cardiomyopathy is one of the characteristic features of cancer. In this study, we establish a
suitable model to study breast cancer-induced cardiomyopathy in mice. We used Ehrlich …

The pathogenesis and treatment of cardiac atrophy in cancer cachexia

KT Murphy - American Journal of Physiology-Heart and …, 2016 - journals.physiology.org
Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of skeletal
muscle mass associated with significant functional impairment. In addition to a loss of …

Cardiac muscle wasting in individuals with cancer cachexia

A Barkhudaryan, N Scherbakov, J Springer… - ESC Heart …, 2017 - Wiley Online Library
Aims Cachexia is a severe complication of cancer that adversely affects the course of the
disease and is associated with high rates of mortality. Patients with cancer manifest …

[HTML][HTML] Cardiac cachexia: perspectives for prevention and treatment

MP Okoshi, RV Capalbo, FG Romeiro… - Arquivos brasileiros de …, 2016 - SciELO Brasil
Cachexia is a prevalent pathological condition associated with chronic heart failure. Its
occurrence predicts increased morbidity and mortality independent of important clinical …

Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model

C Bose, S Awasthi, R Sharma, H Beneš… - PLoS …, 2018 - journals.plos.org
Breast cancer is the most common malignancy in women of the Western world. Doxorubicin
(DOX) continues to be used extensively to treat early-stage or node-positive breast cancer …

Curing breast cancer and killing the heart: a novel model to explain elevated cardiovascular disease and mortality risk among women with early stage breast cancer

AA Kirkham, RI Beaudry, DI Paterson… - Progress in …, 2019 - Elsevier
Due to advances in prevention, early detection and treatment, early breast cancer mortality
has decreased by nearly 40% during the last four decades. Yet, the risk of cardiovascular …