Chronic lymphocytic leukemia (CLL) is a B-cell malignancy, which is associated with
profound alterations and defects in the immune system and a prevalent dependency on the …

Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor
malignancy and suppresses anti-tumor immunity. The context specificity of AHR target …

Chronic lymphocytic leukemia (CLL) is a malignancy of mature, antigen-experienced B
lymphocytes. Despite great progress recently achieved in the management of CLL, the …

T cell exhaustion limits anti-tumor immunity and responses to immunotherapy. Here, we
explored the microenvironmental signals regulating T cell exhaustion using a model of …

T-cell exhaustion, originally described in chronic viral infections, was recently reported in
solid and hematologic cancers. It is not defined whether exhaustion contributes to T-cell …

Blockade of the programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1)
immune checkpoint augments antitumor immunity and induces durable responses in …

Chronic lymphocytic leukemia (CLL) is characterized by apoptosis resistance and a
dysfunctional immune system. Previous reports suggested a potential role of myeloid cells in …

Tumor cell survival critically depends on heterotypic communication with benign cells in the
microenvironment. Here, we describe a survival signaling pathway activated in stromal cells …

CD74 is receptor for the cytokine macrophage migration inhibitory factor (MIF). MIF binding
to CD74 induces a signaling cascade resulting in the release of its cytosolic intracellular …

T-cell defects, immune suppression, and poor antitumor immune responses are hallmarks of
chronic lymphocytic leukemia (CLL), and PD-1/PD-L1 inhibitory signaling has emerged as a …