Mitochondria are essential organelles with numerous functions in cellular metabolism and
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …

A detailed knowledge of the complex processes that make cells and organisms alive is
fundamental in order to understand diseases and to develop novel drugs and therapeutic …

NMR spectroscopy has been applied to cells and tissues analysis since its beginnings, as
early as 1950. We have attempted to gather here in a didactic fashion the broad diversity of …

The mitochondrion is arguably the most complex organelle in the budding yeast cell
cytoplasm. It is essential for viability as well as respiratory growth. Its innermost aqueous …

Members of the coiled-coil-helix-coiled-coil-helix (CHCH) domain-containing protein family
that carry (CX 9 C) type motifs are imported into the mitochondrion with the help of the …

Mitochondrial precursor proteins are synthesized in the cytosol and subsequently imported
into mitochondria. The import of mitochondrial intermembrane space proteins is coupled …

Mitochondria are the central hub of key cellular processes such as energy conversion, cell
signaling, cell cycle regulation and cell differentiation. Therefore, in particular, mitochondrial …

The mitochondrial intermembrane space protein AIFM1 has been reported to mediate the
import of MIA40/CHCHD4, which forms the import receptor in the mitochondrial disulfide …

The mitochondrial intermembrane space hosts a machinery for oxidative protein folding, the
mitochondrial disulfide relay. This machinery imports a large number of soluble proteins into …

Conspectus Cellular structural biology methods are needed to characterize biological
processes at atomic resolution in the physiological environment of the cell. Toward this goal …