The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

BACKGROUND The eukaryotic genome is hierarchically organized in the cell nucleus into
DNA loops, chromatin domains, compartments, and, ultimately, chromosomes. Many of the …

In eukaryotes, DNA is packed inside the cell nucleus in the form of chromatin, which consists
of DNA, proteins such as histones, and RNA. Euchromatin, which is permissive for …

Biochemical reactions are intrinsically stochastic, leading to variation in the production of
mRNAs and proteins within cells. In the scientific literature, this source of variation is typically …

The maternal-to-zygotic transition (MZT) is a key developmental process in metazoan
embryos that involves the activation of zygotic transcription (ZGA) and degradation of …

The awakening of the genome after fertilization is a cornerstone of animal development.
However, the mechanisms that activate the silent genome after fertilization are poorly …

Background Understanding gene transcription and mRNA-protein (mRNP) dynamics in
single cells in a multicellular organism has been challenging. The catalytically dead …

Shadow enhancers, groups of seemingly redundant enhancers, are found in a wide range of
organisms and are critical for robust developmental patterning. However, their mechanism of …

A defining feature of early embryogenesis is the transition from maternal to zygotic control.
This transition requires embryo-wide zygotic genome activation (ZGA), but the extent of …

The responses of plants to their environment are often dependent on the spatiotemporal
dynamics of transcriptional regulation. While live-imaging tools have been used extensively …