Artemisinins as anticancer drugs: Novel therapeutic approaches, molecular mechanisms, and clinical trials

C Xu, H Zhang, L Mu, X Yang - Frontiers in Pharmacology, 2020 - frontiersin.org
Artemisinin and its derivatives have shown broad-spectrum antitumor activities in vitro and in
vivo. Furthermore, outcomes from a limited number of clinical trials provide encouraging …

Artemisinin-type drugs for the treatment of hematological malignancies

RI Mancuso, MA Foglio, ST Olalla Saad - Cancer chemotherapy and …, 2021 - Springer
Qinghaosu, known as artemisinin (ARS), has been for over two millennia, one of the most
common herbs prescribed in traditional Chinese medicine (TCM). ARS was developed as …

Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain

C Ahire, A Nyul‐Toth, J DelFavero, R Gulej… - Aging …, 2023 - Wiley Online Library
Chemotherapy‐induced cognitive impairment (“chemobrain”) is a frequent side‐effect in
cancer survivors treated with paclitaxel (PTX). The mechanisms responsible for PTX …

EGFR promotes the development of triple negative breast cancer through JAK/STAT3 signaling

X Song, Z Liu, Z Yu - Cancer Management and Research, 2020 - Taylor & Francis
Purpose To investigate the role of EGFR and STAT3 in breast cancer development and
progression. Methods Through bioinformatics analysis differently expressed genes (DEGs) …

Dihydroartemisinin: a potential drug for the treatment of malignancies and inflammatory diseases

R Yu, G Jin, M Fujimoto - Frontiers in oncology, 2021 - frontiersin.org
Dihydroartemisinin (DHA) has been globally recognized for its efficacy and safety in the
clinical treatment of malaria for decades. Recently, it has been found that DHA inhibits …

Combination therapy of navitoclax with chemotherapeutic agents in solid tumors and blood cancer: a review of current evidence

NS Nor Hisam, A Ugusman, NF Rajab, MF Ahmad… - Pharmaceutics, 2021 - mdpi.com
Combination therapy emerges as a fundamental scheme in cancer. Many targeted
therapeutic agents are developed to be used with chemotherapy or radiation therapy to …

Antitumor research on artemisinin and its bioactive derivatives

Y Zhang, G Xu, S Zhang, D Wang… - Natural products and …, 2018 - Springer
Cancer is the leading cause of human death which seriously threatens human life. The
antimalarial drug artemisinin and its derivatives have been discovered with considerable …

Nanoparticles formulations of artemisinin and derivatives as potential therapeutics for the treatment of cancer, leishmaniasis and malaria

S Alven, BA Aderibigbe - Pharmaceutics, 2020 - mdpi.com
Cancer, malaria, and leishmaniasis remain the deadly diseases around the world although
several strategies of treatment have been developed. However, most of the drugs used to …

Dihydroartemisinin as a sensitizing agent in cancer therapies

Q Li, Q Ma, J Cheng, X Zhou, W Pu… - OncoTargets and …, 2021 - Taylor & Francis
Cancer is one of the major threats to human health. Although humans have struggled with
cancer for decades, the efficacy of treatments for most tumors is still very limited …

Dihydroartemisinin suppresses STAT3 signaling and Mcl-1 and Survivin expression to potentiate ABT-263-induced apoptosis in Non-small Cell Lung Cancer cells …

X Yan, P Li, Y Zhan, M Qi, J Liu, Z An, W Yang… - Biochemical …, 2018 - Elsevier
Non-small cell lung cancer (NSCLC) is the most common malignancy worldwide. A
significant fraction of NSCLC carries activating mutations in epidermal growth factor receptor …