A highly conserved but convoluted network of neurons and glial cells, the enteric nervous
system (ENS), is positioned along the wall of the gut to coordinate digestive processes and …

The body's microbiome, composed of microbial cells that number in the trillions, is involved
in human health and disease in ways that are just starting to emerge. The microbiome is …

Neural control of the function of visceral organs is essential for homeostasis and health.
Intestinal peristalsis is critical for digestive physiology and host defence, and is often …

The pathophysiology of irritable bowel syndrome (IBS) is multifactorial and probably
involves genetic predisposition and the effect of environmental factors. Unlike other …

Several gastrointestinal (GI) tract abnormalities, including visceral hypersensitivity, motility,
and intestinal permeability alterations, have been implicated in functional GI disorders …

Background & Aims Genetic factors are believed to affect risk for irritable bowel syndrome
(IBS), but there have been no sufficiently powered and adequately sized studies. To identify …

Background Irritable bowel syndrome (IBS) shows genetic predisposition, however, large‐
scale, powered gene mapping studies are lacking. We sought to exploit existing genetic …

Gut dysmotility is associated with constipation, diarrhea, and functional gastrointestinal
disorders like irritable bowel syndrome (IBS), although its molecular underpinnings are …

Recently in Gut, genetic variation affecting ion channels activity has been highlighted in
relation to bowel function and the biology of stool frequency. 1 It is also known that 2% of …

Despite progress describing the effects of persistent organic pollutants (POPs) on the central
nervous system, the effect of POPs on enteric nervous system (ENS) function remains …