Trans-resveratrol (TR) is the biological active isomer of resveratrol and the one responsible
for therapeutic effects; both molecules are non-flavonoid phenolics of the stilbenes class …

Alterations in the epigenome are well known to affect cancer development and progression.
Epigenetics is highly influenced by the environment, including diet, which is a source of …

Numerous studies support the potent anticancer activity of resveratrol and its regulation of
key oncogenic signaling pathways. Additionally, the activation of sirtuin 1, a deacetylase, by …

Phytoestrogens are non-steroidal estrogens produced from plants that can bind with the
human body's estrogenic receptor site and be used as a substitute for maintaining hormonal …

Epigenetic mechanisms play an important role in the etiology of colorectal cancer (CRC)
and other malignancies due, in part, to deregulated bromodomain (BRD) functions …

With the recent advancement of genetic screening for testing susceptibility to mammary
oncogenesis in women, the relevance of the gene− environment interaction has become …

Habitual consumption of certain foods has shown beneficial and protective effects against
multiple chronic diseases. However, it is not clear by which molecular mechanisms they may …

Protein kinase CK2 is an antiapoptotic cancer‐sustaining protein. Curcumin, reported
previously as a CK2 inhibitor, is too bulky to be accommodated in the CK2 active site and …

Natural compounds from diverse sources, including botanicals and commonly consumed
foods and beverages, exert beneficial health effects via mechanisms that impact the …

ABSTRACT Introduction: Bromodomains (BRDs) bind to acetylated lysine residues, often on
histones. The BRD proteins can contribute to gene regulation either directly through …