Genomes have complex three-dimensional architectures. The recent convergence of
genetic, biochemical, biophysical, and cell biological methods has uncovered several …

Cells have a remarkable ability to synthesize large amounts of protein in a very short period
of time. Under these conditions, many hydrophobic surfaces on proteins may be transiently …

This work reviews nuclear compartments, defined broadly to include distinct nuclear
structures, bodies, and chromosome domains. It first summarizes original cytological …

The review begins with a concise description of the principles of phase separation. This is
followed by a comprehensive section on phase separation of chromatin, in which we recount …

The nucleus is a dynamic environment containing chromatin, membraneless organelles,
and specialized molecular structures at the nuclear membrane. Within the spectrum of DNA …

Recent years have provided considerable insights into the dynamic nature of the cell
nucleus, which is constantly reorganizing its genome, controlling its size and shape, as well …

Heterochromatin and euchromatin form different spatial compartments in the interphase
nucleus, with heterochromatin being localized mainly at the nuclear periphery. The …

The dynamic nature of chromosome organization plays a central role in the regulation of
many crucial processes, such as DNA transcription and replication. However, the molecular …

Actin has essential functions both in the cytoplasm and in the nucleus, where it has been
linked to key nuclear processes, from transcription to DNA damage response. The …

The molecular chaperone Hsp90 (Heat shock protein, 90 kDa) is an abundant and essential
cytosolic protein required for the stability and/or folding of hundreds of client proteins …