Given the importance of linkage disequilibrium (LD) in gene mapping and evolutionary
inferences, I characterize in this review the pattern of LD and discuss the influence of human …

Leprosy (Hansen's disease) is a human infectious disease whose etiological agent,
Mycobacterium leprae, was identified by GHA Hansen in the 19th century. Despite the high …

Long tracts of consecutive homozygous single nucleotide polymorphisms (SNPs) can arise
in the genome through a number of mechanisms. These include inbreeding in which an …

Recombination rate and linkage disequilibrium, the latter a function of population genomic
processes, are the critical parameters for mapping by linkage and association, and their …

Genetic susceptibility to multiple sclerosis is associated with genes of the major
histocompatibility complex (MHC), particularly HLA-DRB1 and HLA-DQB1 (ref.). Both locus …

Abstract Background The N-acetyltransferase 2 (NAT2) gene plays a crucial role in the
metabolism of many drugs and xenobiotics. As it represents a likely target of population …

Abstract We developed the SNPlex Genotyping System to address the need for accurate
genotyping data, high sample throughput, study design flexibility, and cost efficiency. The …

The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for
selecting markers for association studies, but it varies between populations. We assayed LD …

Single nucleotide polymorphisms (SNPs) are the most common sequence variation in the
human genome; they have been successfully used in mapping disease genes and more …

The development of genomic resources for wild species is still in its infancy. However, cross‐
species utilization of technologies developed for their domestic counterparts has the …