Prevention, treatment and cure of HIV infection
RJ Landovitz, H Scott, SG Deeks - Nature Reviews Microbiology, 2023 - nature.com
The development of antiretroviral therapy for the prevention and treatment of HIV infection
has been marked by a series of remarkable successes. However, the efforts to develop a …
has been marked by a series of remarkable successes. However, the efforts to develop a …
Mass spectrometry-based structural virology
Here we review recent developments in mass spectrometry that have enabled its growing
contribution to the field of structural virology. Evidently, there is a strong renewed general …
contribution to the field of structural virology. Evidently, there is a strong renewed general …
Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site
TG Caniels, M Medina-Ramìrez, S Zhang… - Science …, 2024 - science.org
Eliciting potent and broadly neutralizing antibodies (bnAbs) is a major goal in HIV-1 vaccine
development. Here, we describe how germline-targeting immunogen BG505 SOSIP …
development. Here, we describe how germline-targeting immunogen BG505 SOSIP …
Allelic polymorphism controls autoreactivity and vaccine elicitation of human broadly neutralizing antibodies against influenza virus
M Sangesland, AT de la Peña, S Boyoglu-Barnum… - Immunity, 2022 - cell.com
Human broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin stalk of group 1
influenza A viruses (IAVs) are biased for IGHV1-69 alleles that use phenylalanine (F54) but …
influenza A viruses (IAVs) are biased for IGHV1-69 alleles that use phenylalanine (F54) but …
Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine …
Uncleaved prefusion-optimized (UFO) design can stabilize diverse HIV-1 envelope
glycoproteins (Envs). Single-component, self-assembling protein nanoparticles (1c-SApNP) …
glycoproteins (Envs). Single-component, self-assembling protein nanoparticles (1c-SApNP) …
Broad and potent neutralizing antibodies recognize the silent face of the HIV envelope
Broadly neutralizing antibodies (bNAbs) against HIV-1 envelope (Env) inform vaccine
design and are potential therapeutic agents. We identified SF12 and related bNAbs with up …
design and are potential therapeutic agents. We identified SF12 and related bNAbs with up …
Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins
Abstract Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses (HNVs) causing
respiratory illness and severe encephalitis in humans, with fatality rates of 50–100%. There …
respiratory illness and severe encephalitis in humans, with fatality rates of 50–100%. There …
Rapid and focused maturation of a VRC01-class HIV broadly neutralizing antibody lineage involves both binding and accommodation of the N276-glycan
Summary The VH1-2 restricted VRC01-class of antibodies targeting the HIV envelope CD4
binding site are a major focus of HIV vaccine strategies. However, a detailed analysis of …
binding site are a major focus of HIV vaccine strategies. However, a detailed analysis of …
Simply extending the mass range in electron transfer higher energy collisional dissociation increases confidence in N-glycopeptide identification
Glycopeptide-centric mass spectrometry has become a popular approach for studying
protein glycosylation. However, current approaches still utilize fragmentation schemes and …
protein glycosylation. However, current approaches still utilize fragmentation schemes and …
Microsecond dynamics control the HIV-1 envelope conformation
AL Bennett, R Edwards, I Kosheleva, C Saunders… - Science …, 2024 - science.org
The HIV-1 Envelope (Env) glycoprotein facilitates host cell fusion through a complex series
of receptor-induced structural changes. Although remarkable progress has been made in …
of receptor-induced structural changes. Although remarkable progress has been made in …