Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with poor prognosis and
limited treatment options. Efforts to identify effective treatments are thwarted by limited …

Immunotherapy has limited response rates in colorectal cancer (CRC) due to an
immunosuppressive tumor microenvironment (TME). Combining transcriptome sequencing …

Breast cancer patients are categorized into three subtypes with distinct treatment
approaches. Precision oncology has increased patient outcomes by targeting the specific …

Heart development relies on a topologically defined interplay between a diverse array of
cardiac cells. We finely curated spatial and single-cell measurements with subcellular …

Physiologically relevant human skin models that include key skin cell types can be used for
in vitro drug testing, skin pathology studies, or clinical applications such as skin grafts …

Background Cancer-associated fibroblasts (CAFs) are the primary stromal cells found in
tumor microenvironment, and display high plasticity and heterogeneity. By using single-cell …

Objective The human adrenal cortex comprises three functionally and structurally distinct
layers that produce layer-specific steroid hormones. With aging, the human adrenal cortex …

Gene expression of single cells mapped in tissue sections Skip to main content Thank you for
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Spatial biology experiments integrate the molecular and histological landscape of tissues to
provide a previously inaccessible view of tissue biology, unlocking the architecture of …

We present STIM, an imaging-based computational framework focused on visualizing and
aligning high-throughput spatial sequencing datasets. STIM is built on the powerful, scalable …