Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis

Y Muta, JF Linares, A Martinez-Ordoñez… - Nature …, 2023 - nature.com
The metabolic and signaling pathways regulating aggressive mesenchymal colorectal
cancer (CRC) initiation and progression through the serrated route are largely unknown …

The relationship between serum lipid levels and colorectal serrated lesions: A systematic review and meta-analysis

X Wang, Y Zou, R Zhang, C Teng, X Ren… - Frontiers in …, 2022 - frontiersin.org
Objective: To clarify the relationship between colorectal serrated lesions and serum lipid
levels, and provide a scientific basis for the identification and early clinical prevention and …

Mechanism of PDZK1 in hepatocellular carcinoma complicated with hyperuricemia

L Guo, W Jiang, L Quan, X Teng, J Zhao… - Journal of …, 2022 - Wiley Online Library
Background. Hepatocellular carcinoma (HCC) is a kind of primary liver cancer that accounts
for more than 90% of primary hepatocellular carcinomas. Hyperuricemia is closely related to …

Risk factors for sessile serrated lesions among Chinese patients undergoing colonoscopy

R Zhang, Y Ni, CLT Guo, RNS Lui… - Journal of …, 2023 - Wiley Online Library
Abstract Background and Aim Serrated polyps have been recognized as a premalignant
lesion accounting for a significant proportion of colorectal cancer. Limited data are available …

[HTML][HTML] Prevalence, risk factors, and BRAF mutation of colorectal sessile serrated lesions among Vietnamese patients

NTH Vu, HM Le, DTN Vo, HA Vu, NQ Le… - World Journal of …, 2024 - ncbi.nlm.nih.gov
BACKGROUND Sessile serrated lesions (SSLs) are considered precancerous colorectal
lesions that should be detected and removed to prevent colorectal cancer. Previous studies …

[HTML][HTML] Different lipid metabolic profiles and their associated genes in sessile serrated adenoma or polyps compared to hyperplastic polyps

C Tang, J Li, Z Yang, Y Chen… - American Journal of …, 2022 - ncbi.nlm.nih.gov
The serrated pathway is important in the development of colorectal cancer; currently,
knowledge about the lipid metabolism profiles of serrated lesions is limited. Clinical …

血脂异常与结直肠锯齿状病变, 结直肠癌相关性研究进展

冉东升, 逯艳艳, 辛春玲, 马颖才 - 中国全科医学, 2024 - chinagp.net
血脂水平异常可能与结直肠肿瘤的发生, 发展有关. 目前, 众多研究证实血脂异常增加了患结直肠
腺瘤的风险, 然而血脂异常与结直肠锯齿状病变, 结直肠癌的关联仍存在争议 …

[HTML][HTML] Risk Factors in Serrated Pathway Lesions: N-Glycosylation Profile as a Potential Biomarker of Progression to Malignancy

H Fernandes-Mendes, CM Azevedo… - GE-Portuguese Journal …, 2024 - karger.com
Introduction: The serrated pathway contributes to interval colorectal cancers, highlighting the
need for new biomarkers to assess lesion progression risk. The β1, 6-GlcNAc branched N …

[HTML][HTML] The Relationship Between Serum Lipids and the Formation of Colorectal Polyps

Y Düzköylü, MK Demircioğlu, H Kılavuz, S Sari - Cureus, 2024 - ncbi.nlm.nih.gov
Background and aims: Obesity, metabolic syndrome, and hyperlipidemia are known as risk
factors for colorectal tumors. Colorectal polyps are accepted as potential precursors of …

The Relationship Between Serum Lipids and the Formation of Colorectal Polyps

D Yiğit, MK Demircioğlu, K Hüseyin, S Serkan - Cureus, 2024 - search.proquest.com
Background and aims: Obesity, metabolic syndrome, and hyperlipidemia are known as risk
factors for colorectal tumors. Colorectal polyps are accepted as potential precursors of …