Voltage-gated calcium channels couple depolarization of the cell-surface membrane to entry
of calcium, which triggers secretion, contraction, neurotransmission, gene expression, and …

Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

Apoptosis linked Gene-2 (ALG-2) is a multifunctional intracellular Ca2+ sensor and the
archetypal member of the penta-EF hand protein family. ALG-2 functions in the repair of …

Neural networks are optimized to detect temporal coincidence on the millisecond timescale.
Here, we offer a synthetic hypothesis based on recent structural insights into SNARE s and …

Many biological processes rely on protein–membrane interactions in the presence of
mechanical forces, yet high resolution methods to quantify such interactions are lacking …

Synaptic communication relies on the fusion of synaptic vesicles with the plasma membrane,
which leads to neurotransmitter release. This exocytosis is triggered by brief and local …

Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how
coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and …

Synaptotagmin (Syt) proteins comprise a 17-member family, many of which trigger
exocytosis in response to calcium. Historically, most studies have focused on the isoform Syt …

diphosphoinositol pentakisphosphate (5-IP7) is a signalling metabolite linked to various
cellular processes. How extracellular stimuli elicit 5-IP7 signalling remains unclear. Here we …

The mechanism of neurotransmitter release has been extensively characterized, showing
that vesicle fusion is mediated by the SNARE complex formed by syntaxin‐1, SNAP‐25 and …