ATRX (alpha-thalassemia mental retardation X-linked) is one of the most frequently mutated
tumor suppressor genes in human cancers, especially in glioma, and recent findings …

The histone variant H3. 3 is implicated in the formation and maintenance of specialized
chromatin structure in metazoan cells. H3. 3-containing nucleosomes are assembled in a …

Gliomas are the most common primary brain tumors in children and adults. We recently
identified frequent alterations in chromatin remodelling pathways including recurrent …

In mammals, DNA methylation is essential for protecting repetitive sequences from aberrant
transcription and recombination. In some developmental contexts (eg, preimplantation …

Classical heterochromatin chromosomal landmarks, such as centromeres and telomeres,
are characterized by specific chromatin signatures. Among these, the incorporation of …

Heterochromatin protein 1 (HP1a) has conserved roles in gene silencing and
heterochromatin and is also implicated in transcription, DNA replication, and repair. Here we …

Heterochromatin is enriched for specific epigenetic factors including Heterochromatin
Protein 1a (HP1a), and is essential for many organismal functions. To elucidate …

The ATRX ATP-dependent chromatin remodelling/helicase protein associates with the
DAXX histone chaperone to deposit histone H3. 3 over repetitive DNA regions. Because …

Histones are essential components of the nucleosome, the major chromatin subunit that
structures linear DNA molecules and regulates access of other proteins to DNA. Specific …

Nuclear DNA in the male gamete of sexually reproducing animals is organized as sperm
chromatin compacted primarily by sperm-specific protamines. Fertilization leads to sperm …