The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …

Over the past decade, genomic analyses of single cells—the fundamental units of life—have
become possible. Single-cell DNA sequencing has shed light on biological questions that …

Faithful DNA replication is essential for genome integrity,,–. Under-replicated DNA leads to
defects in chromosome segregation, which are common during embryogenesis,,–. However …

Successful duplication of the genome requires the accurate replication of billions of base
pairs of DNA within a relatively short time frame. Failure to accurately replicate the genome …

Deoxyribonucleic acid (DNA) replication can be divided into three major steps: initiation,
elongation and termination. Each time a human cell divides, these steps must be …

Mammalian genomes are replicated in a cell type-specific order and in coordination with
transcription and chromatin organization. Currently, single-cell replication studies require …

Replication timing (RT) domains are stable units of chromosome structure that are regulated
in the context of development and disease. Conventional genome-wide RT mapping …

Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is
characterized by frequent appearance of multiradial chromosomes, which are distinctive …

Replication timing (RT) is the temporal order in which genomic DNA is replicated during S
phase. Early and late replication correlate with transcriptionally active and inactive …

DNA replication in stem cells is a major challenge for pluripotency preservation and cell fate
decisions. This process involves massive changes in the chromatin architecture and the …