Currently, there are no clinical drugs available to treat acute kidney injury (AKI). Given the
high prevalence and high mortality rate of AKI, the development of drugs to effectively treat …

Pulmonary hypertension (PH) is a severe disease that affects people of all ages. It can occur
as an idiopathic disorder at birth or as part of a variety of cardiovascular and pulmonary …

Heart valve replacement is an effective therapy for patients with moderate to severe valvular
stenosis or regurgitation. Most bioprosthetic heart valves applied clinically are based on …

BACKGROUND: Cardiac surgery with cardiopulmonary bypass (CPB) is associated with a
high risk of postoperative acute kidney injury (AKI). Due to limitations of current diagnostic …

Introduction: Acute lung injury (ALI) is a devastating pulmonary illness with diffuse
inflammatory responses. Hydromorphone (Hyd) is an opioid agonist used for relieving …

Cardiac surgeries under cardiopulmonary bypass (CPB) are complex procedures with high
incidences of complications, morbidity and mortality. The inhaled nitric oxide (iNO) has been …

Objective To compare the incidence and severity of acute kidney injury (AKI) after cardiac
surgery with cardiopulmonary bypass and the administration of exogenous nitric oxide in …

Objectives Pulmonary hypertension during cardiac surgery is associated with increased
morbidity and mortality. Inhaled nitric oxide serves as a selective pulmonary vasodilator and …

This study aims to determine the effectiveness of administering 80 ppm nitric oxide in
reducing kidney injury, mitochondrial dysfunction and regulated cell death in kidneys during …

Introduction Machine perfusion can enable isolated support of composite tissues, such as
free flaps. The goal of perfusion in this setting is to preserve tissues prior to transplantation …