α-Synucleinopathies comprise a group of neurodegenerative diseases characterized by
altered accumulation of a protein called α-synuclein inside neurons and glial cells. This …

Ferritin is a ubiquitous protein that is present in most tissues as a cytosolic protein. The
major and common role of ferritin is to bind Fe2+, oxidize it and sequester it in a safe form in …

Aging affects iron homeostasis, as evidenced by tissue iron loading and anemia in the
elderly. Iron needs in mammals are met primarily by iron recycling from senescent red blood …

Gaucher disease (GD), a rare hereditary lysosomal storage disorder, occurs due to a
deficiency in the enzyme β-glucocerebrosidase (GCase). This deficiency leads to the …

Anemia and hyperferritinemia are frequent findings at diagnosis of Gaucher disease (GD).
Macrophage-independent dyserythropoiesis and abnormal iron metabolism have been …

Red blood cells (RBC) are the most abundant cells in mammals. Their primary function is
transporting and exchanging O2 and CO2 between the circulation and the organs. Every …

Gaucher Disease (GD) is a rare genetic disorder characterized by a deficiency in the
enzyme glucocerebrosidase, leading to the accumulation of glucosylceramide in various …

Metabolic associated fatty liver disease (MAFLD) consists of lipid accumulation in the liver.
Lipotoxicity, supported by aberrant amino acid metabolism, induces TLR9 upregulation, and …

Sickle cell disease (SCD) is a genetic recessive disorder, characterized by painful episodes
of vaso-occlusion, chronic hemolytic anemia, and progressive organ failure. It is one of the …

Transfusion of red cell concentrates (RCCs) is common for treating anemia in Intensive care
unit (ICU) patients, but it may result in adverse outcomes like sepsis, potentially due to donor …