Targeted alpha therapy: progress in radionuclide production, radiochemistry, and applications

BJB Nelson, JD Andersson, F Wuest - Pharmaceutics, 2020 - mdpi.com
This review outlines the accomplishments and potential developments of targeted alpha (α)
particle therapy (TAT). It discusses the therapeutic advantages of the short and highly …

PSMA-targeted radiopharmaceuticals for imaging and therapy

HJ Wester, M Schottelius - Seminars in nuclear medicine, 2019 - Elsevier
As described in more detail in other contributions in this issue of Seminars in Nuclear
Medicine, prostate-specific membrane antigen (PSMA) has become one of the most …

Exploiting Albumin as a Versatile Carrier for Cancer Theranostics

Y Tao, V Jakobsson, X Chen… - Accounts of Chemical …, 2023 - ACS Publications
Conspectus “Theranostics” is a portmanteau that links the fields of therapeutics and
diagnostics; it describes a personalized medical approach with the expectation to improve …

Preclinical and clinical status of PSMA-targeted alpha therapy for metastatic castration-resistant prostate cancer

A Juzeniene, VY Stenberg, ØS Bruland, RH Larsen - Cancers, 2021 - mdpi.com
Simple Summary Currently, there is no treatment that can cure patients with late stage
metastatic prostate cancer. Prostate-specific membrane antigen is a type of protein …

[HTML][HTML] The salivary glands as a dose limiting organ of PSMA-targeted radionuclide therapy: a review of the lessons learnt so far

N Heynickx, K Herrmann, K Vermeulen… - Nuclear medicine and …, 2021 - Elsevier
At present, prostate cancer remains the second most occurring cancer in men, in Europe.
Treatment efficacy for therapy of advanced metastatic disease, and metastatic castration …

[HTML][HTML] Advances in PSMA theranostics

TM Jeitner, JW Babich, JM Kelly - Translational Oncology, 2022 - Elsevier
The validation of prostate specific membrane antigen (PSMA) as a molecular target in
metastatic castration-resistant prostate cancer has stimulated the development of multiple …

The chemical scaffold of theranostic radiopharmaceuticals: radionuclide, bifunctional chelator, and pharmacokinetics modifying linker

HA Holik, FM Ibrahim, AA Elaine, BD Putra, A Achmad… - Molecules, 2022 - mdpi.com
Therapeutic radiopharmaceuticals have been researched extensively in the last decade as
a result of the growing research interest in personalized medicine to improve diagnostic …

The future of PSMA-targeted radionuclide therapy: an overview of recent preclinical research

EAM Ruigrok, WM van Weerden, J Nonnekens… - Pharmaceutics, 2019 - mdpi.com
Prostate specific membrane antigen (PSMA) has become a major focus point in the research
and development of prostate cancer (PCa) imaging and therapeutic strategies using …

First clinicopathologic evidence of a non–PSMA-related uptake mechanism for 68Ga-PSMA-11 in salivary glands

NJ Rupp, CA Umbricht, DA Pizzuto… - Journal of Nuclear …, 2019 - Soc Nuclear Med
The intense accumulation of prostate-specific membrane antigen (PSMA) radioligands in
salivary glands is still not well understood. It is of concern for therapeutic applications of …

[HTML][HTML] Clinical outcomes and molecular profiling of advanced metastatic castration-resistant prostate cancer patients treated with 225Ac-PSMA-617 targeted alpha …

MJ van der Doelen, N Mehra, IM van Oort… - … Oncology: Seminars and …, 2021 - Elsevier
Introduction Targeted alpha-radiation therapy (TAT) with 225 Ac-labeled prostate-specific
membrane antigen (PSMA) ligands is a promising novel treatment option for metastatic …