Interferon alpha for the adjuvant treatment of cutaneous melanoma
S Mocellin, MB Lens, S Pasquali… - … of systematic reviews, 2013 - cochranelibrary.com
Background Interferon alpha is the only agent approved for the postoperative adjuvant
treatment of high‐risk cutaneous melanoma. However, the survival advantage associated …
treatment of high‐risk cutaneous melanoma. However, the survival advantage associated …
Ubiquitination and deubiquitination of MCL1 in cancer: deciphering chemoresistance mechanisms and providing potential therapeutic options
MCL1 is an important antiapoptotic member of the BCL-2 family that is distinguishable from
other family members based on its relatively short half-life. Emerging studies have revealed …
other family members based on its relatively short half-life. Emerging studies have revealed …
Deubiquitinases (DUBs) and DUB inhibitors: a patent review
P Farshi, RR Deshmukh, JO Nwankwo… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Deubiquitinating-enzymes (DUBs) are key components of the ubiquitin–
proteasome system (UPS). The fundamental role of DUBs is specific removal of ubiquitin …
proteasome system (UPS). The fundamental role of DUBs is specific removal of ubiquitin …
The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor …
Background We characterized the biologic effects of a novel small molecule STAT3 pathway
inhibitor that is derived from the natural product curcumin. We hypothesized this lead …
inhibitor that is derived from the natural product curcumin. We hypothesized this lead …
IL-12 enhances the antitumor actions of trastuzumab via NK cell IFN-γ production
AC Jaime-Ramirez, BL Mundy-Bosse… - The Journal of …, 2011 - journals.aai.org
The antitumor effects of therapeutic mAbs may depend on immune effector cells that express
FcRs for IgG. IL-12 is a cytokine that stimulates IFN-γ production from NK cells and T cells …
FcRs for IgG. IL-12 is a cytokine that stimulates IFN-γ production from NK cells and T cells …
Interferon‑α and its effects on cancer cell apoptosis
W Shi, X Yao, Y Fu, Y Wang - Oncology Letters, 2022 - spandidos-publications.com
Interferon (IFN)‑α is a cytokine that exhibits a wide range of biological activities and is used
in various cancer treatments. It regulates numerous genes that serve roles in antiviral …
in various cancer treatments. It regulates numerous genes that serve roles in antiviral …
PRMT5 Is Upregulated in Malignant and Metastatic Melanoma and Regulates Expression of MITF and p27Kip1
C Nicholas, J Yang, SB Peters, MA Bill, RA Baiocchi… - PLoS …, 2013 - journals.plos.org
Protein arginine methyltransferase-5 (PRMT5) is a Type II arginine methyltransferase that
regulates various cellular functions. We hypothesized that PRMT5 plays a role in regulating …
regulates various cellular functions. We hypothesized that PRMT5 plays a role in regulating …
Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines
The Janus kinase-2 (Jak2)-signal transducer and activator of transcription-3 (STAT3)
pathway is critical for promoting an oncogenic and metastatic phenotype in several types of …
pathway is critical for promoting an oncogenic and metastatic phenotype in several types of …
Low molecular weight polyethylenimine cross-linked by 2-hydroxypropyl-γ-cyclodextrin coupled to peptide targeting HER2 as a gene delivery vector
Gene delivery is one of the critical steps for gene therapy. Non-viral vectors have many
advantages but suffered from low gene transfection efficiency. Here, in order to develop new …
advantages but suffered from low gene transfection efficiency. Here, in order to develop new …
Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells
Previous studies have suggested that the BH3 domain of the proapoptotic Bcl-2 family
member Noxa only interacts with the anti-apoptotic proteins Mcl-1 and A1 but not Bcl-2. In …
member Noxa only interacts with the anti-apoptotic proteins Mcl-1 and A1 but not Bcl-2. In …