The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis

B Sossen, AS Richards, T Heinsohn… - The Lancet …, 2023 - thelancet.com
Stages of tuberculosis disease can be delineated by radiology, microbiology, and
symptoms, but transitions between these stages remain unclear. In a systematic review and …

Cardiovascular involvement in tuberculosis: from pathophysiology to diagnosis and complications—a narrative review

DTM Marcu, CA Adam, F Mitu, C Cumpat… - Diagnostics, 2023 - mdpi.com
Although primarily a lung disease, extra-pulmonary tuberculosis (TB) can affect any organ or
system. Of these, cardiovascular complications associated with disease or drug toxicity …

Estimating the contribution of subclinical tuberculosis disease to transmission: An individual patient data analysis from prevalence surveys

JC Emery, PJ Dodd, S Banu, B Frascella, FL Garden… - Elife, 2023 - elifesciences.org
Background: Individuals with bacteriologically confirmed pulmonary tuberculosis (TB)
disease who do not report symptoms (subclinical TB) represent around half of all prevalent …

PET-CT-guided characterisation of progressive, preclinical tuberculosis infection and its association with low-level circulating Mycobacterium tuberculosis DNA in …

JW Kim, K Bowman, J Nazareth, J Lee… - The Lancet …, 2024 - thelancet.com
Background Incipient tuberculosis, a progressive state of Mycobacterium tuberculosis
infection with an increased risk of developing into tuberculosis disease, remains poorly …

Beyond latent and active tuberculosis: a scoping review of conceptual frameworks

SMA Zaidi, AK Coussens, JA Seddon, T Kredo… - …, 2023 - thelancet.com
There is growing recognition that tuberculosis (TB) infection and disease exists as a
spectrum of states beyond the current binary classification of latent and active TB. Our aim …

Classification of early tuberculosis states to guide research for improved care and prevention: an international Delphi consensus exercise

AK Coussens, SMA Zaidi, BW Allwood… - The Lancet …, 2024 - thelancet.com
The current active–latent paradigm of tuberculosis largely neglects the documented
spectrum of disease. Inconsistency with regard to definitions, terminology, and diagnostic …

Tuberculosis prevalence: beyond the tip of the iceberg

RMGJ Houben, H Esmail, F Cobelens… - The Lancet …, 2022 - thelancet.com
The global burden of tuberculosis disease remains stubbornly high. Population surveys
estimate that 14 million individuals have prevalent disease, reflecting around 10 million …

Clay minerals-based drug delivery systems for anti-tuberculosis drugs

S Saadat, D Rawtani, G Parikh - Journal of Drug Delivery Science and …, 2022 - Elsevier
Clay minerals-based nanocarriers for anti-tuberculosis drugs have attracted a lot of
consideration in recent decades owing to their exceptional characteristics including high …

The Titanic question in TB control: Should we worry about the bummock?

SM Fortune - Proceedings of the National Academy of …, 2024 - National Acad Sciences
In the study of sea ice, the portion of an iceberg that sits below the water is known as the
bummock, counterpart to the hummock, the visible crest of ice. As amateur oceanographers …

Know your tuberculosis epidemic–Is it time to add Mycobacterium tuberculosis immunoreactivity back into global surveillance?

HM Rickman, W Kamchedzera, A Schwalb… - PLOS Global Public …, 2022 - journals.plos.org
Tuberculosis (TB) still causes 1.5 million deaths globally each year. Over recent decades,
slow and uneven declines in TB incidence have resulted in a falling prevalence of TB …