Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core
of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins …

The establishment and maintenance of epithelial cell-cell junctions is crucially important to
regulate adhesion, apico-basal polarity and motility of epithelial cells, and ultimately controls …

Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …

Cadherin genes encode a superfamily of conserved transmembrane proteins that share an
adhesive ectodomain composed of tandem cadherin repeats. More than 100 human …

The shaping of a multicellular body, and the maintenance and repair of adult tissues require
fine-tuning of cell adhesion responses and the transmission of mechanical load between the …

Abstract β-catenin is widely regarded as the primary transducer of canonical WNT signals to
the nucleus. In most vertebrates, there are eight additional catenins that are structurally …

While much work has been done in the design of biomaterials to control integrin‐mediated
adhesion, less emphasis has been put on functionalization of materials with cadherin …

Neurons are highly specialized cells equipped with a sophisticated molecular machinery for
the reception, integration, conduction and distribution of information. The evolutionary origin …

This review focuses on the cell adhesion molecule (CAM), known as neural (N)-cadherin
(CDH2). The molecular basis of N-cadherin-mediated intercellular adhesion is discussed, as …

Members of the cadherin superfamily of proteins are involved in diverse biological
processes such as morphogenesis, sound transduction, and neuronal connectivity. Key to …