Engineering bacteria and bionic bacterial derivatives with nanoparticles for cancer therapy

T Yin, Z Diao, NT Blum, L Qiu, A Ma, P Huang - Small, 2022 - Wiley Online Library
Natural bacteria are interesting subjects for cancer treatments owing to their unique
autonomy‐driven and hypoxic target properties. Genetically modified bacteria (such as …

Bacterial‐Mediated Tumor Therapy: Old Treatment in a New Context

Y Liu, L Niu, N Li, Y Wang, M Liu, X Su, X Bao… - Advanced …, 2023 - Wiley Online Library
Targeted therapy and immunotherapy have brought hopes for precision cancer treatment.
However, complex physiological barriers and tumor immunosuppression result in poor …

Ultrasound-controllable engineered bacteria for cancer immunotherapy

MH Abedi, MS Yao, DR Mittelstein, A Bar-Zion… - Nature …, 2022 - nature.com
Rapid advances in synthetic biology are driving the development of genetically engineered
microbes as therapeutic agents for a multitude of human diseases, including cancer. The …

[HTML][HTML] Bacteria and bacterial derivatives as delivery carriers for immunotherapy

SR Kang, DH Nguyen, SW Yoo, JJ Min - Advanced Drug Delivery Reviews, 2022 - Elsevier
There is growing interest in the role of microorganisms in human health and disease, with
evidence showing that new types of biotherapy using engineered bacterial therapeutics …

Imaging Enterobacterales infections in patients using pathogen-specific positron emission tomography

AA Ordonez, LM Wintaco, F Mota… - Science translational …, 2021 - science.org
Enterobacterales represent the largest group of bacterial pathogens in humans and are
responsible for severe, deep-seated infections, often resulting in sepsis or death. They are …

Acoustically triggered mechanotherapy using genetically encoded gas vesicles

A Bar-Zion, A Nourmahnad, DR Mittelstein… - Nature …, 2021 - nature.com
Recent advances in molecular engineering and synthetic biology provide biomolecular and
cell-based therapies with a high degree of molecular specificity, but limited spatiotemporal …

Bacteria‐mediated tumor therapy via photothermally‐programmed cytolysin a expression

L Wang, W Qin, W Xu, F Huang, X Xie, F Wang, L Ma… - Small, 2021 - Wiley Online Library
By leveraging the ability of bacteria to express therapeutic protein cytolysin A (ClyA) through
plasmid transformation, a thermally‐activated biohybrid (TAB@ Au) is constructed by …

Background-suppressed tumor-targeted photoacoustic imaging using bacterial carriers

R Gao, F Liu, W Liu, S Zeng, J Chen… - Proceedings of the …, 2022 - National Acad Sciences
Photoacoustic (PA) imaging offers promise for biomedical applications due to its ability to
image deep within biological tissues while providing detailed molecular information; …

[HTML][HTML] Recent advances in bacteria-mediated cancer therapy

S Liang, C Wang, Y Shao, Y Wang, D Xing… - … in Bioengineering and …, 2022 - frontiersin.org
Cancer has been regarded as the leading cause of deaths worldwide. Although
conventional therapies have been applied for fighting against the cancer, the poor oxygen …

Hypoxia-targeted and spatial-selective tumor suppression by near infrared nanoantenna sensitized engineered bacteria

C Tao, X Miao, J Yan, X Xiao, R Wu, Q Cao, Z Wang… - Acta Biomaterialia, 2023 - Elsevier
It is an active research area in the development of engineered bacteria to address the
bottleneck issue of hypoxic tumors, which otherwisely possess resistance to …