Mitral regurgitation (MR) is one of the most prevalent valve disorders and has numerous
aetiologies, including primary (organic) MR, due to underlying degenerative/structural mitral …

The increasing complexity of randomized clinical trials and the practice of obtaining a wide
variety of measurements from study participants have made the consideration of multiple …

Objective To evaluate the efficacy and safety of galcanezumab, a humanized monoclonal
antibody that selectively binds to calcitonin gene-related peptide, in the preventive treatment …

The quality of clinical trials is an essential part of the evidence base for the treatment of
headache disorders. In 1991, the International Headache Society Clinical Trials Standing …

Background Opicapone is a novel, once-daily, potent third-generation catechol-O-
methyltransferase inhibitor. We aimed to assess the safety and efficacy of opicapone as an …

Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical
industry, academia, and regulatory agencies, this volume explores the rapidly growing area …

We investigated the genetic overlap between Alzheimer's disease (AD) and Parkinson's
disease (PD). Using summary statistics (P-values) from large recent genome-wide …

Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …

OBJECTIVE: To estimate the efficacy of common treatments for vulvodynia: topical lidocaine
monotherapy, oral desipramine monotherapy, and lidocaine-desipramine combined …

Chinese translation Background: Acupuncture is frequently used to treat seasonal allergic
rhinitis (SAR) despite limited scientific evidence. Objective: To evaluate the effects of …