Aging affects many aspects of everyday living, such as autonomy, security and quality of life.
Among all, spatial memory and spatial navigation show a gradual but noticeable decline, as …

Research involving nonhuman primates (NHPs) has played a vital role in many of the
medical and scientific advances of the past century. NHPs are used because of their …

The mechanisms involved in plasticity in the nervous system are thought to support
cognition, and some of these processes are affected during normal ageing. Notably …

Given the rapid rate of population aging and the increased incidence of cognitive decline
and neurodegenerative diseases with advanced age, it is important to ascertain the …

Executive function (EF) is a complex construct that reflects multiple higher-order cognitive
processes such as planning, updating, inhibiting and set-shifting. Decline in these functions …

It has been postulated that spatial working memory operates optimally within a limited range
of dopamine transmission and D1 dopamine receptor signaling in prefrontal cortex …

Brain networks that engage the hippocampus and prefrontal cortex are central for enabling
effective interactions with our environment. Some of the cognitive processes that these …

An electron microscopic analysis has been carried out on the effects of age on the numerical
density of both excitatory (asymmetric) and inhibitory (symmetric) synapses in the neuropil of …

Patterns of individual differences in cognition have been studied empirically and
systematically in the last decade, but causes and consequences of this variation are still …

The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …