▪ Abstract Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the
presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release …

In 1998 we updated earlier descriptions of the largest family of secondary transport carriers
found in living organisms, the major facilitator superfamily (MFS). Seventeen families of …

Membrane traffic in eukaryotic cells involves transport of vesicles that bud from a donor
compartment and fuse with an acceptor compartment. Common principles of budding and …

Layering of neurons in the cerebral cortex and cerebellum requires Reelin, an extracellular
matrix protein, and mammalian Disabled (mDab1), a cytosolic protein that activates tyrosine …

Current proteomic studies clarified canonical synaptic proteins that are common to many
types of synapses. However, proteins of diversified functions in a subset of synapses are …

Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein common to all synaptic and
endocrine vesicles. Unlike many proteins involved in synaptic exocytosis, SV2 has no …

SV2 proteins are abundant synaptic vesicle proteins expressed in two major (SV2A and
SV2B) and one minor isoform (SV2C) that resemble transporter proteins. We now show that …

The article presents a lecture on the molecular machinery of synaptic neurotransmitter
release. It discusses the speed of synaptic transmission of neurotransmitters, the molecular …

Synapses are not static; their performance is modified adaptively in response to activity.
Presynaptic mechanisms that affect the probability of transmitter release or the amount of …

We describe here the identification and molecular characterization of a new brain protein
that we named SV2C because it is homologous to the synaptic vesicle proteins SV2A and …