Melatonin and mitochondrial function during ischemia/reperfusion injury

Z Ma, Z Xin, W Di, X Yan, X Li, RJ Reiter… - Cellular and Molecular …, 2017 - Springer
Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to
morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine …

Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39

K Devantier, VMS Kjær, S Griffin… - British Journal of …, 2024 - Wiley Online Library
Viroporins possess important potential as antiviral targets due to their critical roles during
virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine …

Utilizing melatonin to alleviate side effects of chemotherapy: a potentially good partner for treating cancer with ageing

Z Ma, L Xu, D Liu, X Zhang, S Di, W Li… - Oxidative medicine …, 2020 - Wiley Online Library
Persistent senescence seems to exert detrimental effects fostering ageing and age‐related
disorders, such as cancer. Chemotherapy is one of the most valuable treatments for cancer …

Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway

H Lan, Y Su, Y Liu, C Deng, J Wang, T Chen… - Life sciences, 2019 - Elsevier
Aims The shortage of donor hearts could be alleviated with the use of the allografts from
donation after circulatory death (DCD). Here, we evaluated the protective effect of melatonin …

In vitro methods for testing antiviral drugs

M Rumlová, T Ruml - Biotechnology advances, 2018 - Elsevier
Despite successful vaccination programs and effective treatments for some viral infections,
humans are still losing the battle with viruses. Persisting human pandemics, emerging and …

Targeting human proteins for antiviral drug discovery and repurposing efforts: a focus on protein kinases

R Hajjo, DA Sabbah, OH Abusara, R Kharmah… - Viruses, 2023 - mdpi.com
Despite the great technological and medical advances in fighting viral diseases, new
therapies for most of them are still lacking, and existing antivirals suffer from major limitations …

CP204L is a multifunctional protein of African swine fever virus that interacts with the VPS39 subunit of the homotypic fusion and vacuole protein sorting complex and …

KM Dolata, W Fuchs, G Caignard, J Dupré… - Journal of …, 2023 - Am Soc Microbiol
Virus replication depends on a complex interplay between viral and host proteins. In the
case of African swine fever virus (ASFV), a large DNA virus, only a few virus-host protein …

Differences in oligomerization of the SARS-CoV-2 envelope protein, poliovirus VP4, and HIV Vpu

JA Townsend, O Fapohunda, Z Wang, H Pham… - Biochemistry, 2024 - ACS Publications
Viroporins constitute a class of viral membrane proteins with diverse roles in the viral life
cycle. They can self-assemble and form pores within the bilayer that transport substrates …

Modulation of protein oligomerization: an overview

N Kumari, S Yadav - Progress in Biophysics and Molecular Biology, 2019 - Elsevier
A large section of cellular proteins in both prokaryotic and eukaryotic systems have
oligomeric property. Intently, oligomerization of protein is an invaluable phenomenon from …

Retroviral hijacking of host transport pathways for genome nuclear export

RT Behrens, NM Sherer - Mbio, 2023 - Am Soc Microbiol
Recent advances in the study of virus-cell interactions have improved our understanding of
how viruses that replicate their genomes in the nucleus (eg, retroviruses, hepadnaviruses …