Inflammation is a complex biological response fundamental to how the body deals with
injury and infection to eliminate the initial cause of cell injury and effect repair. Unlike a …

Abstract Interleukin-33 (IL-33) is a member of the IL-1 family and plays an ambivalent role in
autoimmune diseases. IL-33 signals via the ST2 receptor and drives cytokine production in …

Demyelination is a hallmark of multiple sclerosis, leukoencephalopathies, cerebral
vasculopathies, and several neurodegenerative diseases. The cuprizone mouse model is …

Multiple sclerosis is an immune-mediated chronic inflammatory disease of the CNS that
leads to demyelinated lesions in the grey and white matter. Inflammatory, active …

With the advent of an aging society, the incidence of dementia is increasing, resulting in a
vast burden on society. It is increasingly acknowledged that neuroinflammation is implicated …

The perspective of neuroinflammation as an epiphenomenon following neuron damage is
being replaced by the awareness of glia and their importance in neural functions and …

The cellular and molecular basis of sex-dimorphic autoimmune diseases, such as the CNS
demyelinating disease multiple sclerosis (MS), remains unclear. Our studies in the SJL …

Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is involved in various diseases.
IL-33 exerts its effects via its heterodimeric receptor complex, which comprises suppression …

Traumatic brain injury (TBI) is a devastating condition due to its long-term sequelae on
neurological functions. Inflammatory responses after TBI are critical for injury expansion and …

ST2, the receptor for the alarmin IL-33, is expressed by a subset of regulatory T (T reg) cells
residing in nonlymphoid tissues, and these cells can potently expand upon provision of …