Interactions between the foreign body reaction and Staphylococcus aureus biomaterial-associated infection. Winning strategies in the derby on biomaterial implant …

CWK Rosman, JM van Dijl… - Critical Reviews in …, 2022 - Taylor & Francis
Biomaterial-associated infections (BAIs) are an increasing problem where antibiotic
therapies are often ineffective. The design of novel strategies to prevent or combat infection …

Trained immunity as a preventive measure for surgical site infections

L Ter Steeg, J Domínguez-Andrés… - Clinical Microbiology …, 2021 - Am Soc Microbiol
Even with strict implementation of preventive measures, surgical site infections (SSIs)
remain among the most prevalent health care-associated infections. New strategies to …

A novel oral vaccine delivery system for enhancing stability and immune protection: bacterium-like particle with functional coating

X De, M Gao, Z Jia, H Ren, R Liu, X Zhou… - Frontiers in …, 2024 - frontiersin.org
Bacterium-like particles (BLPs) have gained significant attention in vaccine development
due to their potential as effective immune enhancers and antigen delivery systems. BLPs are …

Semaglutide outperforms insulin in restoring neutrophil function against implant-related infection in diabetic and obese mice: experimental research

T Liu, L Zhou, Y Chen, J Lin, H Zhu - International Journal of …, 2024 - journals.lww.com
Background: Bone and joint infections (BJI) are a significant complication after arthroplasty
and fracture fixation, particularly challenging in patients with type 2 diabetes mellitus (T2DM) …

Immune-based anti-Staphylococcal therapeutic approaches

B Park, GY Liu - Microorganisms, 2021 - mdpi.com
Widespread methicillin-resistant Staphylococcus aureus (S. aureus) infections within
community and healthcare settings are responsible for accelerated development of antibiotic …

Trained Immunity Causes Myeloid Cell Hypercoagulability

AM Rehill, S McCluskey, AE Ledwith, TAJ Ryan… - bioRxiv, 2024 - biorxiv.org
Venous thromboembolism is common in individuals with chronic inflammatory diseases, but
the pathogenic basis for this increased thrombotic risk remains poorly understood. Myeloid …

Does preoperative glycemic control restore immune defense against implant-related infection in mice with diabetes?

J Lin, T Huang, H Wei, B Bao, T Gao… - Clinical Orthopaedics …, 2022 - journals.lww.com
Background The presence of Type II diabetes is a well-established risk factor for bone and
joint infection, especially in patients with poor glycemic control. However, few studies have …

[PDF][PDF] Interactions between the foreign body reaction and Staphylococcus aureus biomaterial-associated infection.

CWK Rosman, JM van Dijl, J Sjollema - … aureus nuclease: a target …, 2022 - research.rug.nl
Biomaterial-associated infections (BAIs) are an increasing problem where antibiotic
therapies are often ineffective. The design of novel strategies to prevent or combat infection …

CORR Insights®: Does Training Innate Immunity Confer Broad-spectrum Protection Against Bone and Joint Infection in a Mouse Model?

L Morawietz - Clinical Orthopaedics and Related Research®, 2020 - journals.lww.com
Despite appropriate perioperative antibiotic prophylaxis, postoperative infections
nevertheless occur; they cause great harm to our patients and they are difficult to treat. This …

Platelets mediate trained immunity against bone and joint infections in a mouse model

T Gao, J Lin, H Wei, B Bao, H Zhu… - Bone & Joint …, 2022 - boneandjoint.org.uk
Aims Trained immunity confers non-specific protection against various types of infectious
diseases, including bone and joint infection. Platelets are active participants in the immune …