Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease

N Kumar, V Kumar, P Anand, V Kumar… - Bioorganic & Medicinal …, 2022 - Elsevier
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

Recent Developments in Enantioselective Nickel (II)‐Catalyzed Conjugate Additions

H Pellissier - Advanced Synthesis & Catalysis, 2015 - Wiley Online Library
During the last ten years, an important number of novel highly efficient asymmetric conjugate
additions of various nucleophiles to numerous acceptor‐activated olefins have been …

Reductive Heck cyclization of cage containing compounds: Convenient access to adamantyl-substituted indolines and spiro-homoadamantane-oxindole

AN Reznikov, MA Ashatkina, SY Vostruhina… - Tetrahedron …, 2023 - Elsevier
Sterically hindered cage substrates with exo-and endocyclic double bonds were first used
as substrates in the intramolecular reductive Heck reaction. The Pd (II) complex with an …

An efficient green synthesis and in vitro evaluation of novel adamantane-containing 4-thiazolidinone derivatives as anticancer agents

MA Aras, N Jafari, AM Zonouz… - Journal of Molecular …, 2025 - Elsevier
The novel 4-thiazolidinone derivatives incorporating an adamantane moiety were
synthesized in high yields through the reaction of N-adamantyl-substituted thioureas and …

DFT insight into mechanism of the Ni (II)-catalyzed enantioselective Michael addition: A combined computational and experimental study

VA Shiryaev, DS Nikerov, AN Reznikov… - Molecular …, 2021 - Elsevier
The features of asymmetric Ni (II)-catalyzed Michael addition of 1, 3-dicarbonyl compounds
to nitroolefins has been investigated by DFT and experimental studies. The results support a …

Synthesis and Evaluation of the Psychotropic Activity of Framework Derivatives of Alpha-Pyrrolidone

YN Klimochkin, IM Tkachenko, AN Reznikov… - Russian Journal of …, 2021 - Springer
Derivatives of alpha-pyrrolidone and some derivatives of adamantane possess a wide
spectrum of psychotropic activity. The synthesis of adamantane and homoadamantane …

Synthesis of non-racemic 4-nitro-2-sulfonylbutan-1-ones via Ni (II)-catalyzed asymmetric Michael reaction of β-ketosulfones

AN Reznikov, AE Sibiryakova… - Beilstein Journal of …, 2019 - beilstein-journals.org
Functionally substituted sulfones with stereogenic centers are valuable reagents in organic
synthesis and key motifs in some bioactive compounds. The asymmetric Michael addition of …

Organic Chemistry in Russian Universities. Achievements of Recent Years

II Stoikov, IS Antipin, VA Burilov… - Russian Journal of …, 2024 - Springer
An overview of the main scientific achievements of Russian universities in the field of
organic chemistry over the period 2018–2023 is presented.

Синтез и оценка психотропной активности каркасных производных альфа-пирролидона

ЮН Климочкин, ИМ Ткаченко, АН Резников… - Биоорганическая …, 2021 - elibrary.ru
Производные альфа-пирролидона и некоторые производные адамантана обладают
широким спектром психотропной активности. Осуществлен синтез и проведена оценка …

Organic Transformations with MeNO 2

D Das, N Patil, BM Bhanage - The Chemical Transformations of …, 2022 - Wiley Online Library
Nitromethane is the simplest organic nitro compound, which is used not only as a solvent but
also as a substantial building block for a variety of important compounds such as …