A growing number of studies now suggest that the cellular mechanisms which normally
participate in signaling in the central nervous system (CNS) can be transformed by disease …

Recent studies suggest that excitatory amino acids (EAAs) have a wide variety of
physiological and pathophysiological roles during central nervous system (CNS) …

Perinatal cerebral hypoxia–ischemia remains a frequent cause of the chronic handicapping
conditions of cerebral palsy, mental retardation, learning disability, and epilepsy. 1 …

The expression of two alternative splice variants, Flip and Flop, in mRNAs encoding the four
AMPA-selective glutamate receptors (GIuR-A,-B, 4, and-D) was studied in the developing …

The ontogeny of radioligand binding toN-methyl-d-aspartate and quisqualate receptors in rat
forebrain was studied quantitatively usingin vitro receptor autoradiography. Specific binding …

There is growing evidence that a large number of very low birth weight infants are exhibiting
neurobehavioral problems in the absence of cerebral palsy at follow-up that has extended …

Excitotoxicity is an important mechanism involved in perinatal brain injuries. Glutamate is the
major excitatory neurotransmitter, and most neurons as well as many oligodendrocytes and …

Hypoxia threatens brain function during the entire life-span starting from early fetal age up to
senescence. This review compares the short-term, long-term and life-spanning effects of …

The neurotoxic lesion produced by direct injection of 25 nmol ofN-methyl-d-aspartate
(NMDA) into the corpus striatum of 7-day-old rats was compared to the effects of injecting 75 …

PURPOSE Our purpose was to report the patterns of injury observed in five patients who
suffered brain damage consequent to neonatal hypoglycemia. METHODS The imaging …