Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …

Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

Abstract The Diels–Alder reaction is one of the most powerful and widely used methods in
synthetic chemistry for the stereospecific construction of carbon–carbon bonds. Despite the …

The calculation of accurate reaction energies and barrier heights is essential in
computational studies of reaction mechanisms and thermochemistry. To assess methods …

Diels–Alder reactions are among the most powerful synthetic transformations to construct
complex natural products. Despite that increasing of enzymatic intramolecular Diels–Alder …

Abstract Natural Diels–Alderases that selectively form endo or exo products are increasingly
well known but generally form one stereoisomer with limited substrate scope. Here we report …

The pericyclases are a growing superfamily of enzymes that catalyze pericyclic reactions.
We report a pericyclase IccD catalyzing an inverse-electron demand Diels–Alder (IEDDA) …

Covering: up to August 2020 The dramatic increase in the identification of dimeric natural
products generated by microorganisms and plants has played a significant role in drug …

In this review, we discuss novel natural products discovered within the last decade that are
reported to have antifungal activity against pathogenic species. Nearly a hundred natural …

Penicillium, one of the most common fungi occurring in a diverse range of habitats, has a
worldwide distribution and a large economic impact on human health. Hundreds of the …