Molecular mechanisms of varicella zoster virus pathogenesis

L Zerboni, N Sen, SL Oliver, AM Arvin - Nature reviews microbiology, 2014 - nature.com
Varicella zoster virus (VZV) is the causative agent of varicella (chickenpox) and zoster
(shingles). Investigating VZV pathogenesis is challenging as VZV is a human-specific virus …

Manipulation of the innate immune response by varicella zoster virus

C Gerada, TM Campbell, JJ Kennedy… - Frontiers in …, 2020 - frontiersin.org
Varicella zoster virus (VZV) is the causative agent of chickenpox (varicella) and shingles
(herpes zoster). VZV and other members of the herpesvirus family are distinguished by their …

[HTML][HTML] The role of PI3K/Akt in human herpesvirus infection: from the bench to the bedside

XQ Liu, JI Cohen - Virology, 2015 - Elsevier
Abstract The phosphatidylinositol-3-kinase (PI3K)-Akt signaling pathway regulates several
key cellular functions including protein synthesis, cell growth, glucose metabolism, and …

Single-cell mass cytometry analysis of human tonsil T cell remodeling by varicella zoster virus

N Sen, G Mukherjee, A Sen, SC Bendall, P Sung… - Cell reports, 2014 - cell.com
Although pathogens must infect differentiated host cells that exhibit substantial diversity,
documenting the consequences of infection against this heterogeneity is challenging. Single …

Modifications of the PI3K/Akt/mTOR axis during FeHV-1 infection in permissive cells

G Ferrara, C Longobardi, S Damiano… - Frontiers in Veterinary …, 2023 - frontiersin.org
FeHV-1 is the causative agent of infectious rhinotracheitis in cats. The relationship between
viral infection and the PI3K/Akt/mTOR pathway, as well as its function in crucial physiological …

Herpes simplex virus protein kinases US3 and UL13 modulate VP11/12 phosphorylation, virion packaging, and phosphatidylinositol 3-kinase/Akt signaling activity

HE Eaton, HA Saffran, FW Wu, K Quach… - Journal of …, 2014 - Am Soc Microbiol
ABSTRACT The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway plays key roles
in diverse cellular activities and promotes cell growth and survival. It is therefore …

A pseudorabies virus serine/threonine kinase, US3, promotes retrograde transport in axons via Akt/mToRC1

AD Esteves, OO Koyuncu, LW Enquist - Journal of Virology, 2022 - Am Soc Microbiol
Infection of peripheral axons by alpha herpesviruses (AHVs) is a critical stage in
establishing a lifelong infection in the host. Upon entering the cytoplasm of axons, AHV …

ORF7 of varicella-zoster virus is required for viral cytoplasmic envelopment in differentiated neuronal cells

HF Jiang, W Wang, X Jiang, WB Zeng, ZZ Shen… - Journal of …, 2017 - Am Soc Microbiol
Although a varicella-zoster virus (VZV) vaccine has been used for many years, the
neuropathy caused by VZV infection is still a major health concern. Open reading frame 7 …

The human adenovirus E4-ORF1 protein subverts discs large 1 to mediate membrane recruitment and dysregulation of phosphatidylinositol 3-kinase

K Kong, M Kumar, M Taruishi, RT Javier - PLoS pathogens, 2014 - journals.plos.org
Adenoviruses infect epithelial cells lining mucous membranes to cause acute diseases in
people. They are also utilized as vectors for vaccination and for gene and cancer therapy, as …

Creating the “Dew Drop on a Rose Petal”: the Molecular Pathogenesis of Varicella-Zoster Virus Skin Lesions

AM Arvin - Microbiology and Molecular Biology Reviews, 2023 - Am Soc Microbiol
Varicella-zoster virus (VZV) is a human alphaherpesvirus that causes varicella (chicken pox)
as the primary infection in a susceptible host. Varicella is very contagious through its …