Structural insights of oxindole based kinase inhibitors as anticancer agents: Recent advances
P Dhokne, AP Sakla, N Shankaraiah - European journal of medicinal …, 2021 - Elsevier
Small-molecule kinase inhibitors are being continuously explored as new anticancer
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …
A mini review on isatin, an anticancer scaffold with potential activities against neglected tropical diseases (NTDs)
Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …
therapeutic fragments in drug design and development. The template has turned out to be …
New quinoxaline-2 (1 H)-ones as potential VEGFR-2 inhibitors: Design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations
Eleven new quinoxaline derivatives were designed and synthesized as modified VEGFR-2
inhibitors of our previous work. The synthesized compounds were tested against three …
inhibitors of our previous work. The synthesized compounds were tested against three …
Discovery of new quinoxaline-2 (1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation
VEGF/VEGFR2 pathway is the crucial therapeutic target in the treatment of cancer. So that, a
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …
Design, synthesis, and anti-proliferative evaluation of new quinazolin-4 (3H)-ones as potential VEGFR-2 inhibitors
K El-Adl, AGA El-Helby, RR Ayyad, HA Mahdy… - Bioorganic & Medicinal …, 2021 - Elsevier
Inhibiting VEGFR-2 has been set up as a therapeutic strategy for treatment of cancer. Thus,
nineteen new quinazoline-4 (3H)-one derivatives were designed and synthesized …
nineteen new quinazoline-4 (3H)-one derivatives were designed and synthesized …
Novel oxindole/benzofuran hybrids as potential dual CDK2/GSK-3β inhibitors targeting breast cancer: design, synthesis, biological evaluation, and in silico studies
The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic …
New EGFR inhibitor series of fifteen 5-chloro-3-hydroxymethyl-indole-2-carboxamide
derivatives has been designed, synthesized, and tested for antiproliferative activity against a …
derivatives has been designed, synthesized, and tested for antiproliferative activity against a …
Novel 2-indolinone thiazole hybrids as sunitinib analogues: Design, synthesis, and potent VEGFR-2 inhibition with potential anti-renal cancer activity
Novel 2-indolinone thiazole hybrids were designed and synthesized as VEGFR-2 inhibitors
based on sunitinib, an FDA-approved anticancer drug. The proposed structures of the …
based on sunitinib, an FDA-approved anticancer drug. The proposed structures of the …
Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi‐active components combination
W Zhao, XD Zheng, PYZ Tang, HM Li… - Medicinal Research …, 2023 - Wiley Online Library
The antitumor efficacy of Chinese herbal medicines has been widely recognized. Leading
compounds such as sterols, glycosides, flavonoids, alkaloids, terpenoids …
compounds such as sterols, glycosides, flavonoids, alkaloids, terpenoids …
Novel benzenesulfonamides as dual VEGFR2/FGFR1 inhibitors targeting breast cancer: Design, synthesis, anticancer activity and in silico studies
RM Hassan, IH Ali, AM El Kerdawy, MT Abo-Elfadl… - Bioorganic …, 2024 - Elsevier
In the current study, a new series of benzenesulfonamides 6a-r was designed and
synthesized as dual VEGFR-2 and FGFR1 kinase inhibitors with anti-cancer activity. The 4 …
synthesized as dual VEGFR-2 and FGFR1 kinase inhibitors with anti-cancer activity. The 4 …