Bacterial survival within a mammalian host is contingent upon sensing environmental
perturbations and initiating an appropriate counter-response. To achieve this, sophisticated …

The BCL2 family plays important roles in acute myeloid leukemia (AML). Venetoclax, a
selective BCL2 inhibitor, has received FDA approval for the treatment of AML. However …

The protein-ligand binding frequently occurs in living organisms and plays a crucial role in
the execution of the functions of proteins and drugs. It is also an indispensable part of drug …

The identification of new drugs for novel therapeutic targets requires the screening of
libraries containing tens of thousands of compounds. While experimental screenings are …

Malaria eradication is a global health priority, but current therapies are not always suitable
for providing a radical cure. Artemisinin has paved the way for the current malaria treatment …

The ClpB–DnaK bichaperone system reactivates aggregated cellular proteins and is
essential for survival of bacteria, fungi, protozoa, and plants under stress. AAA+ ATPase …

Hsp100 chaperones, also known as Clp proteins, constitute a family of ring-forming
ATPases that differ in 3D structure and cellular function from other stress-inducible …

Highlights•Protein quality control components mediate survival upon a plethora of
stresses.•A transmissible locus for protein quality control (TLPQC-1) has been …

The oligomeric AAA+ chaperones Hsp104 in yeast and ClpB in bacteria are responsible for
the reactivation of aggregated proteins, an activity essential for cell survival during severe …

This review focuses on the molecular chaperone ClpB that belongs to the Hsp100/Clp
subfamily of the AAA+ ATPases and its biological function in selected bacterial pathogens …