Takotsubo syndrome: translational implications and pathomechanisms

X Fan, G Yang, J Kowitz, I Akin, X Zhou… - International journal of …, 2022 - mdpi.com
Takotsubo syndrome (TTS) is identified as an acute severe ventricular systolic dysfunction,
which is usually characterized by reversible and transient akinesia of walls of the ventricle in …

[HTML][HTML] Human induced pluripotent stem cell (hiPSC)-derived cardiomyocyte modelling of cardiovascular diseases for natural compound discovery

K Zhu, X Bao, Y Wang, T Lu, L Zhang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Cardiovascular disease (CVD) remains the leading cause of death worldwide. Natural
compounds extracted from medicinal plants characterized by diverse biological activities …

Short QT syndrome: a comprehensive genetic interpretation and clinical translation of rare variants

O Campuzano, A Fernandez-Falgueras… - Journal of clinical …, 2019 - mdpi.com
Short QT syndrome, one of the most lethal entities associated with sudden cardiac death, is
a rare genetic disease characterized by short QT intervals detected by electrocardiogram …

Drug development and the use of induced pluripotent stem cell-derived cardiomyocytes for disease modeling and drug toxicity screening

P Ovics, D Regev, P Baskin, M Davidor… - International Journal of …, 2020 - mdpi.com
Over the years, numerous groups have employed human induced pluripotent stem cell-
derived cardiomyocytes (iPSC-CMs) as a superb human-compatible model for investigating …

Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene‐edited human‐induced pluripotent stem cell …

I El‐Battrawy, H Lan, L Cyganek… - Clinical and …, 2021 - Wiley Online Library
Dear Editor, In the present study, we show that the Calcium Voltage-Gated Channel
Auxiliary Subunit Beta 2 (CACNB2) variant c. 1439C> T/p. S480L is linked to the clinical …

Preclinical short QT syndrome models: Studying the phenotype and drug-screening

X Fan, G Yang, J Kowitz, F Duru, AM Saguner… - EP …, 2022 - academic.oup.com
Cardiovascular diseases are the main cause of sudden cardiac death (SCD) in developed
and developing countries. Inherited cardiac channelopathies are linked to 5–10% of SCDs …

Ventricular voltage‐gated ion channels: Detection, characteristics, mechanisms, and drug safety evaluation

L Chen, Y He, X Wang, J Ge, H Li - Clinical and Translational …, 2021 - Wiley Online Library
Cardiac voltage‐gated ion channels (VGICs) play critical roles in mediating cardiac
electrophysiological signals, such as action potentials, to maintain normal heart excitability …

Impact of antiarrhythmic drugs on the outcome of short QT syndrome

I El-Battrawy, J Besler, X Li, H Lan, Z Zhao… - Frontiers in …, 2019 - frontiersin.org
Short QT syndrome (SQTS) is associated with sudden cardiac arrest. There are limited data
on the impact of antiarrhythmic drugs on the outcome of SQTS. Materials and Methods: We …

Latent causes of sudden cardiac arrest

AD Krahn, J Tfelt-Hansen, R Tadros, C Steinberg… - Clinical …, 2022 - jacc.org
Inherited arrhythmia syndromes are a common cause of apparently unexplained cardiac
arrest or sudden cardiac death. These include long QT syndrome and Brugada syndrome …

Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes

KH Jæger, S Wall, A Tveito - PLoS computational biology, 2021 - journals.plos.org
Short QT (SQT) syndrome is a genetic cardiac disorder characterized by an abbreviated QT
interval of the patient's electrocardiogram. The syndrome is associated with increased risk of …