Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care

H Breiteneder, Z Diamant, T Eiwegger, WJ Fokkens… - Allergy, 2019 - Wiley Online Library
The specialties of allergy and clinical immunology have entered the era of precision
medicine with the stratification of diseases into distinct disease subsets, specific diagnoses …

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia

KS Robinson, DET Teo, KS Tan, GA Toh, HH Ong… - Science, 2020 - science.org
INTRODUCTION The innate immune system uses a variety of sensor proteins to detect
infections and injuries. The nucleotide-binding oligomerization domain, leucine-rich repeat …

The role of miR‐146a in viral infection

JS Nahand, MR Karimzadeh, M Nezamnia… - IUBMB …, 2020 - Wiley Online Library
Cellular microRNAs (miRNAs) were identified as a key player in the posttranscriptional
regulation of cellular‐genes regulatory pathways. They also emerged as a significant …

Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles

AM Gamage, KS Tan, WOY Chan, J Liu, CW Tan… - PLoS …, 2020 - journals.plos.org
The novel coronavirus SARS-CoV-2 is the causative agent of Coronavirus Disease 2019
(COVID-19), a global healthcare and economic catastrophe. Understanding of the host …

Calcitriol, the active form of vitamin D, is a promising candidate for COVID-19 prophylaxis

CK Mok, YL Ng, BA Ahidjo, RC Hua Lee, MW Choy Loe… - BioRxiv, 2020 - biorxiv.org
COVID-19, the disease caused by SARS-CoV-2, was declared a pandemic by the World
Health Organization (WHO) in March 2020. While awaiting a vaccine, several antivirals are …

Respiratory viral infections in exacerbation of chronic airway inflammatory diseases: novel mechanisms and insights from the upper airway epithelium

KS Tan, RL Lim, J Liu, HH Ong, VJ Tan… - Frontiers in cell and …, 2020 - frontiersin.org
Respiratory virus infection is one of the major sources of exacerbation of chronic airway
inflammatory diseases. These exacerbations are associated with high morbidity and even …

In vitro model of fully differentiated human nasal epithelial cells infected with rhinovirus reveals epithelium-initiated immune responses

KS Tan, HH Ong, Y Yan, J Liu, C Li… - The Journal of …, 2018 - academic.oup.com
Human rhinoviruses (HRVs) are the commonest cause of the common cold. While HRV is
less pathogenic than other respiratory viruses, it is frequently associated with exacerbation …

Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

R Li, L Wang - Molecular Medicine Reports, 2019 - spandidos-publications.com
Influenza virus A (IVA) is one of the predominant causative agents of the seasonal flu and
has become an important cause of morbidity worldwide. Great efforts have been paid to …

H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells

C Liu, X Wu, X Bing, W Qi, F Zhu, N Guo, C Li… - Free Radical Biology …, 2023 - Elsevier
Influenza A virus can induce nasal inflammation by stimulating the death of nasal mucosa
epithelium, however, the mechanism is not clear. In this study, to study the causes and …

Impact of respiratory virus infections in exacerbation of acute and chronic rhinosinusitis

KS Tan, Y Yan, HH Ong, VTK Chow, L Shi… - Current allergy and …, 2017 - Springer
Rhinosinusitis (RS) is a symptomatic disease classification of many causes and is a major
economic burden worldwide. It is widely accepted that RS is further classified into acute …